Search results for PAPSS1

Showing 13 results out of 13

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Protein (3 results from a total of 3)

Identifier: R-HSA-174387
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PAPSS1: O43252
Identifier: R-HSA-6802543
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PAPSS1: O43252
Identifier: R-HSA-6802432
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: O43252

Complex (2 results from a total of 2)

Identifier: R-HSA-6802696
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-6802603
Species: Homo sapiens
Compartment: cytosol

Set (1 results from a total of 1)

Identifier: R-HSA-174400
Species: Homo sapiens
Compartment: cytosol

Reaction (6 results from a total of 6)

Identifier: R-HSA-2408540
Species: Homo sapiens
Compartment: cytosol
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthases 1 and 2 (PAPSS1,2) (Venkatachalam et al. 1998, Xu et al. 2000) are involved in phosphorylating adenylylselenate (APSe) into 3'-phosphoadenylyl selenate (PAPSe) via its APS kinase domain. This reaction is inferred from the event in Penicillium chrysogenum involving APS kinase (Kaps) (Yu et al. 1989).
Identifier: R-HSA-2408525
Species: Homo sapiens
Compartment: cytosol
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthases 1 and 2 (PAPSS1,2) (Venkatachalam et al. 1998, Xu et al. 2000) are involved in transforming adenosine triphosphate (ATP) and selenic acid (H2SeO4) into adenylylselenate (APSe) and diphosphate via its ATP sulphurylase domain. This reaction is inferred from the event in rat (Yu et al. 1989).
Identifier: R-HSA-174392
Species: Homo sapiens
Compartment: cytosol
In the first step of PAPS biosynthesis, ATP and sulfate react to form adenylyl sulfate (APS) and pyrophosphate (PPi), catalyzed by the ATP sulfurylase domains of the bifunctional enzymes PAPS synthases 1 and 2 (PAPSS1 and 2). PAPSS2 is essential for the sulfation of glycosaminoglycan chains in proteoglycans, a necessary post translational modification. Defective PAPSS2 results in undersulfation of the glycosaminoglycan chains in proteoglycans which causes spondyloepimetaphyseal dysplasia Pakistani type (SEMD PA; MIM:612847), a bone disease characterized by epiphyseal dysplasia with mild metaphyseal abnormalities. Mutations resulting in SEMD PA include S438*, T48R and R329* (Ahmad et al. 1998, ul Haque et al. 1998, Noordam et al. 2009).
Identifier: R-HSA-174389
Species: Homo sapiens
Compartment: cytosol
In the second step of PAPS biosynthesis, adenylyl sulfate (APS) is phosphorylated to 3'-phosphoadenylyl sulfate (PAPS), catalyzed by the APS kinase domains of the bifunctional enzymes PAPS synthases 1 and 2 (PAPSS1 and 2). PAPSS2 is essential for the sulfation of glycosaminoglycan chains of proteoglycans, a necessary post-translational modification. Defective PAPSS2 results in undersulfation of proteoglycans which causes spondyloepimetaphyseal dysplasia Pakistani type (SEMD-PA; MIM:612847), a bone disease characterized by epiphyseal dysplasia with mild metaphyseal abnormalities. Mutations resulting in SEMD-PA include S438*, T48R and R329* (Ahmad et al. 1998, ul Haque et al. 1998, Noordam et al. 2009).
Identifier: R-HSA-3560785
Species: Homo sapiens
Compartment: cytosol
In the second step of PAPS biosynthesis, adenylyl sulfate (APS) is phosphorylated to 3'-phosphoadenylyl sulfate (PAPS), catalyzed by the APS kinase domains of the bifunctional enzymes PAPS synthases 1 and 2 (PAPSS1 and 2). PAPSS2 is essential for the sulfation of glycosaminoglycan chains of proteoglycans, a necessary post-translational modification. Defective PAPSS2 results in undersulfation of proteoglycans which causes spondyloepimetaphyseal dysplasia Pakistani type (SEMD-PA; MIM:612847), a bone disease characterized by epiphyseal dysplasia with mild metaphyseal abnormalities. Mutations resulting in SEMD-PA include S438*, T48R and R329* (Ahmad et al. 1998, ul Haque et al. 1998, Noordam et al. 2009).
Identifier: R-HSA-3560794
Species: Homo sapiens
Compartment: cytosol
In the first step of PAPS biosynthesis, ATP and sulfate react to form adenylyl sulfate (APS) and pyrophosphate (PPi), catalyzed by the ATP sulfurylase domains of the bifunctional enzymes PAPS synthases 1 and 2 (PAPSS1 and 2). PAPSS2 is essential for the sulfation of glycosaminoglycan chains in proteoglycans, a necessary post translational modification. Defective PAPSS2 results in undersulfation of the glycosaminoglycan chains in proteoglycans which causes spondyloepimetaphyseal dysplasia Pakistani type (SEMD PA; MIM:612847), a bone disease characterized by epiphyseal dysplasia with mild metaphyseal abnormalities. Mutations resulting in SEMD PA include S438*, T48R and R329* (Ahmad et al. 1998, ul Haque et al. 1998, Noordam et al. 2009).

Pathway (1 results from a total of 1)

Identifier: R-HSA-2408550
Species: Homo sapiens
Ingested selenic acid (H2SeO4) and selenite (SeO3(2-)) are reduced to hydrogen selenide (H2Se) through a combination of actions involving bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 and 2 (PAPSS1/2), PAPSe reductase (PAPSeR), and thioredoxin reductase 1 (TXNRD1).
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