Search results for POM121

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Reaction (2 results from a total of 2)

Identifier: R-HSA-9618378
Species: Homo sapiens
Compartment: cytosol, nuclear envelope
Based on studies in Xenopus (Fichtman et al. 2010) and human (Schwartz et al. 2015) models, POM121 binds the Nup107-160 complex through direct interaction with NUP133, a subunit of the Nup107-160 complex. Binding of POM121 to the Nup107-160 complex precedes formation of the nuclear pore diffusion barrier (Dultz et al. 2008), and is followed by recruitment of FG repeat nucleoporins (Fichtman et al. 2010). FG nucleoporins contain phenylalanine-glycine repeats needed for interaction with soluble nuclear import and export receptors (Frey et al. 2006).
Identifier: R-HSA-9634169
Species: Homo sapiens
Compartment: cytosol, nuclear envelope
From studies with Xenopus and human model systems, the transmembrane nucleoporins POM121 and NDC1 recruit the NUP93 complex to nascent nuclear pore complexes (NPCs) due to interaction with the NUP93 complex components NUP155 (Mitchell et al. 2010) and, potentially, NUP35 (Mansfield et al. 2006). This is consistent with order-of-assembly seen in live cell imaging (Dultz et al. 2008).
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