Search results for PTGIS

Showing 3 results out of 3

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Species

Types

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Species

Types

Compartments

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-62410
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: PTGIS: Q16647

Set (1 results from a total of 1)

Identifier: R-HSA-3222410
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.

Reaction (1 results from a total of 1)

Identifier: R-HSA-76496
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, endoplasmic reticulum lumen
Prostacyclin synthase (PTGIS) aka CYP8A1 mediates the isomerisation of prostaglandin H2 (PGH2) to prostaglandin I2 (PGI2) aka prostacyclin (Wada et al. 2004). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH. Experiments on rats with thrombolytic models suggest endogenous MNA could be a stimulator of the COX2/PGI2 pathway and thus regulate an anti-thrombotic effect (Chlopicki et al. 2007).
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