Search results for RLBP1

Showing 13 results out of 13

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Protein (2 results from a total of 2)

Identifier: R-HSA-74928
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: RLBP1: P12271
Identifier: R-HSA-2984237
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: P12271

Reaction (7 results from a total of 7)

Identifier: R-HSA-2465971
Species: Homo sapiens
Compartment: cytosol
Retinaldehyde-binding protein 1 (RLBP1, also called cellular retinaldehyde-binding protein, CRALBP) (Crabb et al. 1998) binds 11cROL (He et al. 2009) and is thought to enhance the activity of isomerase II and ARAT in experiments performed in cone-rich eyes from chickens (Mata et al. 2002, Mata et al. 2005).
Identifier: R-HSA-2454264
Species: Homo sapiens
Compartment: cytosol
Cellular retinaldehyde-binding protein (RLBP1, CRALBP) (Intres et al. 1994) is abundant in retinal pigment epithelium (RPE) and Muller cells of the retina where it plays a role in sequestering 11-cis retinoids produced during the retinoid cycle. The natural ligands are 11-cis-retinol (11cROL) and 11-cis-retinal (11cRAL) (Crabb et al. 1998).
Identifier: R-HSA-8960973
Species: Homo sapiens
Compartment: cytosol
Interphotoreceptor retinoid-binding protein (RBP3) is the major soluble protein in the interphotoreceptor matrix (IPM) (Liou et al. 1989, Fong & Bridges 1988). It is thought to shuttle 11-cis-retinal (11cRAL) between retinal pigment epithelium (RPE) and photoreceptor outer segments during the visual cycle but the mechanism is poorly understood (Gonzalez-Fernandez & Ghosh 2008). It is assumed cellular retinaldehyde-binding protein (RLBP1) must dissociate from 11cRAL before 11cRAL is transported as RLBP1 is not present in photoreceptor cells.
Identifier: R-HSA-2454081
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, cytosol
Another member of the short-chain dehydrogenases/reductases (SDR) family, RDH5, can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells using NAD+ as cofactor (Simon et al. 1996, Gonzalez-Fernandez et al. 1999). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.
Identifier: R-HSA-74872
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane, cytosol
Using NADP+ as cofactor, several members of the short-chain dehydrogenases/reductases (SDR) family can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells. Retinol dehydrogenases 10 and 11 (RDH10 and 11) are two such members utilizing the cofactor NADP+ (Wu et al. 2002, Kedishvili et al. 2002 respectively). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.
Identifier: R-HSA-2466832
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
11-cis-retinol dehydrogenase (RDH5) can reversibly catalyse the oxidation of all-trans-retinol (atROL, bound to RLBP1) to all-trans-retinal (atRAL) in retinal pigment epithelium (RPE) cells using NAD+ as cofactor. Defective RDH5 causes retinitis punctata albescens (RPA, also called fundus albipunctatus, FA; MIM:136880). RPA (an autosomal recessive disorder) is a form of stationary congenital night blindness characterised by a reduced regeneration rate of rod and cone photoreceptors and yellow-white lesions within the retina or the RPE. Mutations causing RPA include G238W (Gonzalez-Fernandez et al. 1999, Yamamoto et al. 1999), R280H (Gonzalez-Fernandez et al. 1999, Kuroiwa et al. 2000, Nakamura et al. 2000), A294P (Gonzalez-Fernandez et al. 1999), V177G (Gonzalez-Fernandez et al. 1999, Kuroiwa et al. 2000) and R157W (Cideciyan et al. 2000).
Identifier: R-HSA-2465919
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
The esterification of alcohols with fatty acids is the favoured mechanism to form esterified forms of sterols, di- and triacylglycerols, and retinoids for storage. In the RPE and Muller cells of the eye, formation of retinyl esters is an essential step in the enzymatic regeneration of the visual chromophore 11-cis-retinal (11cRAL). Acyl-CoA wax alcohol acyltransferase 2 (AWAT2, aka Multifunctional O-acyltransferase, MFAT) (Yen et al. 2005) is an ER-membrane protein with a broad substrate specificity that can also esterify 11-cis retinol (11cROL) (Kaylor et al. 2014). The most common fatty acid is palmitate, forming retinyl palmitate (11cRPALM). Retinyl esters form into lipid droplets called retinosomes. In the previous step, retinol isomerase activity produces a mixture of retinol isomers (9-cis, 11-cis, 13-cis and all-trans-retinol) of which 11cROL only constitutes around 1% of the mixture. AWAT2’s preferential activity towards 11cROL has been proposed to be due to an allosteric modulation of AWAT2 by either bound (to RLBP1) or free 11cis-retinyl esters such as 11cRPALM. 11cRPALM impedes the acyl transfer onto 9-cis, 13-cis and all-trans retinols by making allosterically-induced changes in the active site of AWAT2 (Arne et al. 2017).

Complex (4 results from a total of 4)

Identifier: R-HSA-2465956
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-2454078
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-2454060
Species: Homo sapiens
Compartment: cytosol
Identifier: R-HSA-8981408
Species: Homo sapiens
Compartment: cytosol
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