Search results for RND1

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Reaction (9 results from a total of 9)

Identifier: R-HSA-9696274
Species: Homo sapiens
Compartment: cytosol, plasma membrane
RND1 binds GTP with approximately 100 times higher affinity than GDP and is thus considered to be constitutively active (Nobes et al. 1998).
Identifier: R-HSA-9696271
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Active GTP-bound RND1 binds the following effectors:
ARHGAP5 (Wennerberg et al. 2003; Bagci et al. 2020)
FRS2 (Harada et al. 2005)
FRS3 (Harada et al. 2005)
GRB7 (Vayssiere et al. 2000)
PLEKHG5 (Goh and Manser 2010)
PLXNA1 (Zanata et al. 2002)
STIP1 (de Souza et al. 2014)
STMN2 (Li et al. 2009)
UBXN11 (Katoh et al. 2002)

The following candidate RND1 effectors were reported in the high throughput screen by Bagci et al. 2020 or have been reported as RND1 effectors in some but not all studies:
ALDH3A2 (Bagci et al. 2020)
ANKRD26 (Bagci et al. 2020)
ARHGAP35 (Wennerberg et al. 2003, Mori et al. 2009: binding to active RND1; Bagci et al. 2020: no binding to active RND1)
CAV1 (Bagci et al. 2020)
CCDC88A (Bagci et al. 2020)
CPD (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DSP (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
EPSTI1 (Bagci et al. 2020)
FAM135A (Bagci et al. 2020)
FAM83B (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
KIDINS220 (Bagci et al. 2020)
KIF14 (Bagci et al. 2020)
LEMD3 (Bagci et al. 2020)
MUC13 (Bagci et al. 2020)
PKP4 (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
PTPN13 (Bagci et al. 2020)
RASAL2 (Bagci et al. 2020)
RBMX (Bagci et al. 2020)
RRAS2 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VANGL2 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)

RND1 does not interact with the following putative effectors that bind to active RND2 and/or RND3:
CKAP4 (Bagci et al. 2020)
CKB (Bagci et al. 2020)
DDX4 (Bagci et al. 2020)
DSG1 (Bagci et al. 2020)
FNBP1 (Bagci et al. 2020)
GOLGA3 (Bagci et al. 2020)
KTN1 (Bagci et al. 2020)
LRRC1 (Bagci et al. 2020)
NISCH (Bagci et al. 2020)
NUDC (Bagci et al. 2020)
PICALM (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
SEMA4F (Bagci et al. 2020)
TMOD3 (Bagci et al. 2020)
UHRF1BP1L (Bagci et al. 2020)
Identifier: R-HSA-399928
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Binding of Sema3A to the Neuropilin-1-Plexin-A receptor complex results in the recruitment of Rnd1 to the cytoplasmic linker region of Plexin-A. Rnd1 activates the cytoplasmic GTPase signaling domain of Plexin-A.
Identifier: R-HSA-400677
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Rnd1 is constitutively active and stably associates with Plexin-B1 and regulates the R-Ras GAP activity of the C1 and C2 domains of the Plexin-B1 cytoplasmic tail. These domains interact with each other and in this closed conformation cannot associate with active R-Ras-GTP. Rnd1 binds to the region between C1 and C2 domains and disrupts this interaction, allowing the receptor to associate with GTP-bound R-Ras.
Identifier: R-HSA-9696268
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Active GTP bound RND3 binds the following effectors:
ARHGAP5 (Wennerberg et al. 2003; Bagci et al. 2020)
KCTD13 (Gladwyn Ng et al. 2016)
PLEKHG5 (Goh and Manser 2010)
ROCK1 (Riento et al. 2003) RND3 inhibits kinase activity of ROCK1
TNFAIP1 (Gladwyn Ng et al. 2016)
UBXN11 (Katoh et al. 2002)

The following candidate RND3 effectors were reported in the high throughput screen by Bagci et al. 2020 or were reported by some but not all studies:
ANKRD26 (Bagci et al. 2020)
ARHGAP21 (Bagci et al. 2020)
ARHGAP35 (Wennerberg et al. 2003: binding to active RND3; Bagci et al. 2020: no binding to active RND3)
CAV1 (Bagci et al. 2020)
CCDC88A (Bagci et al. 2020)
CKAP4 (Bagci et al. 2020)
CKB (Bagci et al. 2020)
CPD (Bagci et al. 2020)
DDX4 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DSG1 (Bagci et al. 2020)
DSP (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
FAM83B (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
KTN1 (Bagci et al. 2020) - RND3 has not been shown to localize to the endoplasmic reticulum membrane, but some isoforms of KTN1 have been shown to localize to the plasma membrane (Santama et al. 2004)
LEMD3 (Bagci et al. 2020)
MUC13 (Bagci et al. 2020)
NISCH (Bagci et al. 2020)
PICALM (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
PKP4 (Bagci et al. 2020)
PTPN13 (Bagci et al. 2020)
RASAL2 (Bagci et al. 2020)
RBMX (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
SEMA4F (Bagci et al. 2020)
TMOD3 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VANGL2 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)

RND3 does not interact with the following effectors:
ALDH3A2 (Bagci et al. 2020)
EPSTI1 (Bagci et al. 2020)
FAM135A (Bagci et al. 2020)
FNBP1 (Bagci et al. 2020)
FRS2 (Harada et al. 2005)
FRS3 (Harada et al. 2003)
GOLGA3 (Bagci et al. 2020)
KIDINS220 (Bagci et al. 2020)
KIF14 (Bagci et al. 2020)
LRRC1 (Bagci et al. 2020)
NUDC (Bagci et al. 2020)
ROCK2 (Riento et al. 2003)
RRAS2 (Bagci et al. 2020)
STMN2 (Li et al. 2009)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
UHRF1BP1L (Bagci et al. 2020)
Identifier: R-HSA-416588
Species: Homo sapiens
Compartment: cytosol, plasma membrane
The RhoGEFs LARG and PDZ-RhoGEF complexed with Plexin-B1 stimulate the exchange of GDP for GTP on RhoA through their DH and PH domains.
Identifier: R-HSA-9696266
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Active GTP bound RND2 binds the following effectors:
ARHGAP5 (Wennerberg et al. 2003; Bagi et al. 2020)
FNBP1 (Fujita et al. 2002; Kakimoto et al. 2004; Bagci et al. 2020)
FRS2 (Harada et al. 2005)
FRS3 (Harada et al. 2005)
KCTD13 (Gladwyn Ng et al. 2016)
PLXND1 (Uesugi et al. 2009)
PRAG1 (Tanaka et al. 2006)
TNFAIP1 (Gladwyn Ng et al. 2015; Gladwyn Ng et al. 2016)
UBXN11 (Katoh et al. 2002)

RND2 binds to the following candidate effectors reported in the high throughput screen by Bagci et al. 2020 or reported in some but all studies:
ALDH3A2 (Bagci et al. 2020)
ANKRD26 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP35 (Wennerberg et al. 2003: binding to active RND2; Bagci et al. 2020: no binding to active RND2)
CAV1 (Bagci et al. 2020)
CKAP4 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DSG1 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
FAM83B (Bagci et al. 2020)
GOLGA3 (Bagci et al. 2020)
KIDINS220 (Bagci et al. 2020)
KIF14 (Bagci et al. 2020)
KTN1 (Bagci et al. 2020) - while RND2 has not been shown to localize to the endoplasmic reticulum membrane (ER), some isoforms of KTN1 are known to localize to the plasma membrane instead of the ER membrane (Santama et al. 2004)
LEMD3 (Bagci et al. 2020)
LRRC1 (Bagci et al. 2020)
MUC13 (Bagci et al. 2020)
NISCH (Bagci et al. 2020)
NUDC (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
PKP4 (Bagci et al. 2020)
PTPN13 (Bagci et al. 2020)
RBMX (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
UHRF1BP1L (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VANGL2 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)

RND2 does not bind the following effectors:
CCDC88A (Bagci et al. 2020)
CKB (Bagci et al. 2020)
CPD (Bagci et al. 2020)
DDX4 (Bagci et al. 2020)
DSP (Bagci et al. 2020)
EPSTI1 (Bagci et al. 2020)
FAM135A (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
GRB7 (Vayssiere et al. 2000)
PLEKHG5 (Goh and Manser 2010)
PICALM (Bagci et al. 2020)
RASAL2 (Bagci et al. 2020)
RRAS2 (Bagci et al. 2020)
SEMA4F (Bagci et al. 2020)
STIP1 (de Souza et al. 2014)
STMN2 (Li et al. 2009)
TMEM59 (Bagci et al. 2020)
TMOD3 (Bagci et al. 2020)
Identifier: R-HSA-416594
Species: Homo sapiens
Compartment: cytosol, plasma membrane
Plexin-B1 activates RhoA and induces growth cone collapse and and cytoskeletal reorganization through Rho-specific guanine nucleotide exchange factors PDZ-RhoGEF (ARHGEF11) and leukemia-associated RhoGEF (LARG, ARHGEF12). Plexin-B1 directly interacts with PDZ-RhoGEF through its c-terminal PDZ domain binding motif. It has been suggested that Rnd1, which binds to the cytoplasmic part of plexin-B1, can promote the interaction between plexin-B1 and PDZ-RhoGEF. The PDZ domain of LARG is directly involved in the interaction with the c-terminal sequence of Plexin-B1.
Identifier: R-HSA-399938
Species: Homo sapiens
Compartment: cytosol
Sema3A-mediated dissociation of FARP2 from Plexin-A is followed by activation of Rac1 by the GEF activity of released FARP2.
FARP2 is critical for Sema3A-mediated axonal repulsion through two independent downstream signaling pathways. Sema3A mediated disassociation of FARP2 from Plexin-A is followed by activation of Rac by GEF activity of released FARP2, binding of Rnd1 to plexin-A and down regulation of R-Ras by GAP activity of plexin-A.
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