Search results for SLC25A6

Showing 4 results out of 4

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Species

Types

Compartments

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Protein (2 results from a total of 2)

Identifier: R-HSA-49745
Species: Homo sapiens
Compartment: mitochondrial inner membrane
Primary external reference: UniProt: SLC25A6: P12236
Identifier: R-HSA-1955374
Species: Homo sapiens
Compartment: mitochondrial intermembrane space
Primary external reference: UniProt: SLC25A6: P12236

Complex (1 results from a total of 1)

Identifier: R-HSA-77449
Species: Homo sapiens
Compartment: mitochondrial inner membrane

Reaction (1 results from a total of 1)

Identifier: R-HSA-163215
Species: Homo sapiens
Compartment: mitochondrial inner membrane
A family of antiport, ATP-ADP translocases (SLC25A4,5,6), preferentially export ATP from the matrix while importing ADP from the cytosol, thereby maintaining a high ADP:ATP ratio in the matrix. When there are increased energy demands on the body, such as under heavy exercise, cytosolic ADP rises and is exchanged with mitochondrial matrix ATP via the transmembrane ADP:ATP translocase. Increased ADP causes the proton-motive force to be discharged and protons enter via ATPase, thereby regenerating the ATP pool.
There are 3 isoforms of translocases in humans; isoform 1 (SLC25A4) is the heart/skeletal muscle form, isoform 2 (SLC25A5) is the fibroblast form and isoform 3 (SLC25A6) is the liver form. All isoforms exist as homodimers.
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