Search results for TCF3

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Reaction (8 results from a total of 8)

Identifier: R-HSA-6801213
Species: Homo sapiens
Compartment: nucleoplasm, mitochondrial intermembrane space
Binding of TP53 (p53) to the p53 response element in the second intron of the TRIAP1 (TP53-regulated inhibitor of apoptosis, also known as p53 survival factor or p53CSV) gene induces TRIAP1 transcription (Park and Nakamura 2005). Recently, TRIAP1 has been characterized as a gene-specific repressor of p21 (CDKN1A). TRIAP1 knockdown leads to augmented p21 expression before and during p53 activation and thus slows down cell proliferation (Andrysik et al. 2013).
Identifier: R-HSA-8951428
Species: Homo sapiens
Compartment: nucleoplasm
RUNX3 forms a ternary complex with beta-catenin (CTNNB1) and its binding partner TCF7L2 (TCF4). In addition to TCF7L2, RUNX3 is also able to interact with LEF1, TCF7L1 (TCF3) and TCF7 (also known as TCF1). The interaction involves the Runt domain of RUNX3 and the HMG box of TCF7L2 (Ito et al. 2008).
Identifier: R-HSA-8956568
Species: Homo sapiens
Compartment: nucleoplasm
RUNX1, in complex with CBFB, binds to the core TAL1 complex consisting of TAL1 (SCL), TCF3 (E2A) or TCF12 (HEB), LMO1 or LMO2, LDB1 and GATA1, GATA2 or GATA3 (Wilson et al. 2010, Tijssen et al. 2011, Sanda et al. 2012, Mansour et al. 2014, Hoang et al. 2016). Assembly of the RUNX1- and GATA3-containing TAL1 complex is positively regulated by the CDK7-containing CAK complex (Kwiatkowski et al. 2014).
Identifier: R-HSA-4411357
Species: Homo sapiens
Compartment: nucleoplasm
TCF7L1 (also known as TCF3), TCF7L3 (also known as LEF1) and TCF7L2 (also known as TCF4) have been demonstrated to bind to the MYC gene in vivo and in vitro and to mediate beta-catenin dependent transcription (Park et al, 2009; He et al, 1998; Sierra et al, 2006). Aberrant beta-catenin dependent activation of the MYC gene contributes to oncogenic signaling and cellular proliferation in colorectal and other cancers (see for instance Sansom et al, 2007; Moumen et al, 2013; reviewed in Wilkins and Sansom, 2008; Cairo et al, 2012).
Binding of RUNX3 to the CTNNB1:TCF7L2 and possibly to the CTNNB1:LEF1 and TCF7L1 complexes, prevents binding of CTNNB1 complexes to the MYC promoter, thus negatively regulating MYC transcription (Ito et al. 2008).
Identifier: R-HSA-4411367
Species: Homo sapiens
Compartment: nucleoplasm
TCF7L1 (also known as TCF3), TCF7L3 (also known as LEF1) and TCF7L2 (also known as TCF4) have been demonstrated to bind to the MYC gene in vivo and in vitro and to mediate beta-catenin dependent transcription (Park et al, 2009; He et al, 1998; Sierra et al, 2006). Aberrant beta-catenin dependent activation of the MYC gene contributes to oncogenic signaling and cellular proliferation in colorectal and other cancers (see for instance Sansom et al, 2007; Moumen et al, 2013; reviewed in Wilkins and Sansom, 2008; Cairo et al, 2012).
Binding of RUNX3 to the CTNNB1:TCF7L2 and possibly to the CTNNB1:LEF1 and TCF7L1 complexes, prevents binding of CTNNB1 complexes to the MYC promoter, thus negatively regulating MYC transcription (Ito et al. 2008).
Identifier: R-HSA-8944352
Species: Homo sapiens
Compartment: nucleoplasm
TCF7 (TCF1), LEF1, TCF7L1 (TCF3) and TCF7L2 (TCF4) are HMG box-containing DNA-binding proteins that recognize WNT-responsive elements (WREs) in the promoters of WNT target genes. The WRE consensus sequence is CCTTTGWW, where W represents either T or A (reviewed in Brantjes et al, 2002). In the absence of a WNT signal, promoter-bound TCF/LEF is bound by one of four Groucho homologues, TLE1, 2, 3 or 4 (Levanon et al, 1998; Brantjes et al, 2001; Daniels and Weis, 2005). Groucho/TLE proteins are co-repressors for a variety of DNA-binding transcription factors and mediate repression at least in part through their interaction with histone deacetylases such as RPD3/HDAC1 (Arce et al, 2009; Brantjes et al, 2001; Chen et al, 1999; reviewed in Chen and Courey, 2000).
Identifier: R-HSA-4641229
Species: Homo sapiens
Compartment: nucleoplasm
TCF1, LEF1, TCF3 and TCF4 are HMG box-containing DNA-binding proteins that recognize WNT-responsive elements (WREs) in the promoters of WNT target genes (reviewed in Brantjes et al, 2002). In the absence of a WNT signal, promoter-bound TCF/LEF is bound by one of four Groucho homologues, TLE1, 2, 3 or 4 (Levanon et al, 1998; Brantjes et al, 2001; Daniels and Weis, 2005). Groucho/TLE proteins are co-repressors for a variety of DNA-binding transcription factors and mediate repression at least in part through their interaction with histone deacetylases such as RPD3/HDAC1 (Arce et al, 2009; Brantjes et al, 2001; Chen et al, 1999; reviewed in Chen and Courey, 2000). Groucho proteins have been shown to homo-tetramerize through a glutamine rich Q domain at the N-terminus, and this oligomerization is required for repression. The Q domain is also sufficient for interaction with TCF/LEF proteins (Brantjes et al, 2001; Chen et al, 1998; Pinto and Lobe, 1996; Song et al, 2004). Studies with purified proteins have shown that human TLE1 and 2 bind to an amino-terminal truncated form of LEF1(69-397) with an affinity comparable to that for full length LEF1 (Daniels and Weis, 2005).
Identifier: R-HSA-3299569
Species: Homo sapiens
Compartment: nucleoplasm
TCF7 (TCF1), LEF1, TCF7L1 (TCF3) and TCF7L2 (TCF4) are HMG box-containing DNA-binding proteins that recognize WNT-responsive elements (WREs) in the promoters of WNT target genes. The WRE consensus sequence is CCTTTGWW, where W represents either T or A (reviewed in Brantjes et al, 2002). In the absence of a WNT signal, promoter-bound TCF/LEF is bound by one of four Groucho homologues, TLE1, 2, 3 or 4 (Levanon et al, 1998; Brantjes et al, 2001; Daniels and Weis, 2005). Groucho/TLE proteins are co-repressors for a variety of DNA-binding transcription factors and mediate repression at least in part through their interaction with histone deacetylases such as RPD3/HDAC1 (Arce et al, 2009; Brantjes et al, 2001; Chen et al, 1999; reviewed in Chen and Courey, 2000). Groucho proteins have been shown to homo-tetramerize through a glutamine rich Q domain at the N-terminus, and this oligomerization is required for repression. The Q domain is also sufficient for interaction with TCF/LEF proteins (Brantjes et al, 2001; Chen et al, 1998; Pinto and Lobe, 1996; Song et al, 2004). Studies with purified proteins have shown that human TLE1 and 2 bind to an amino-terminal truncated form of LEF1(69-397) with an affinity comparable to that for full length LEF1 (Daniels and Weis, 2005)
Evidence suggests that upon activation of the WNT pathway, TLE proteins are displaced from TCF/LEF complexes by competition with nuclear beta-catenin. A primary N-terminal beta-catenin binding site has been defined on TCF/LEF. Beta-catenin binds this region of TCF/LEF through ARM domains 3-8; beta-catenin residues D19 and E27 are essential for this interaction (van de Wetering et al, 1997; Graham et al, 2000). The beta-catenin binding site on TCF/LEF does not overlap with the putative TLE binding site and is not required for TLE binding (Daniels and Weis, 2005; Poy et al, 2001; Graham et al, 2000; von Kries et al, 2000; Omer et al, 1999; Korinek et al, 1998; Behrens et al, 1996; Molenaar et al, 1996, van de Wetering et al, 1997). Limited proteolysis and competition studies with purified proteins suggests that TLEs and beta-catenin share a secondary C-terminal binding site on LEF-1; competition for this binding site is proposed to trigger the switch from repressive to activating complexes at the promoters of WNT target genes, though this may not be universally true at all WNT-responsive promoters (Daniels and Weis, 2005).
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