Search results for TKT

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Reaction (6 results from a total of 6)

Identifier: R-HSA-9761834
Species: Homo sapiens
Compartment: nucleoplasm
The TKT gene encodes transketolase, an enzyme that catalyzes two reversible reactions in the non-oxidative branch of the pentose phosphate pathway (PPP). Both TKT reactions consume (or produce, depending on direction) intermediates that are shared between PPP and glycolysis, positioning TKT as a key regulator of carbon flux between alternate glucose metabolism pathways (reviewed in Ge et al, 2020).
Expression of a number of genes involved in the pentose phosphate pathway, including TKT, have been shown to be regulated by NFE2L2 downstream of KEAP1. NFE2L2 was initially characterized as a transcription factor involved in antioxidant response and maintenance of cellular redox balance but has also been shown to be a critical regulator of metabolic reprogramming, including during oncogenesis (reviewed in Baird and Yamamoto, 2020; Ge et al, 2020; Smolkova et al, 2020). NFE2L2 binds to antioxidant response (ARE) elements in the promoter of target genes as a heterodimer with a member of the small MAF family of proteins. NFE2L2 upregulates expression in response to NFE2L2 inducers and has been shown to bind directly to the TKT promoter by ChIP-seq (Thimmulappa et al, 2002; Wu et al, 2011; Mitsuishi et al, 2012; Tang et al, 2021; reviewed in Ge et al, 2020).
Identifier: R-HSA-9761852
Species: Homo sapiens
Compartment: nucleoplasm, cytosol
Transketolase (TKT) encodes an enzyme responsible for two reversible reactions of the non-oxidative branch of the pentose phosphate pathway (PPP). The PPP branches off from glycolysis and diverts carbon metabolites into other biosynthetic pathways to generate NADPH, fatty acids, sterols and nucleic acids, among others (reviewed in Ge et al, 2020). NFE2L2 is a transcription factor with key roles in antioxidant response, redox balance, NADPH generation and metabolic reprogramming, including during oncogenesis (reviewed in Baird and Yamamoto, 2020; Ge et al, 2020; Smolkova et al 2020). NFE2L2 binds as a heterodimer with a member of the MAF protein family to antioxidant response elements in the promoters of target genes, including TKT and other enzymes in the PPP (Tang et al, 2021; reviewed in Baird and Yamamoto; Ge et al, 2020).
Identifier: R-HSA-163751
Species: Homo sapiens
Compartment: cytosol
Cytosolic transketolase (TKT) catalyzes the reaction of D-glyceraldehyde 3-phosphate and D-fructose 6-phosphate to form D-erythrose 4-phosphate and D-xylulose 5-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).
Identifier: R-HSA-71335
Species: Homo sapiens
Compartment: cytosol
Cytosolic transketolase (TKT) catalyzes the reaction of D-erythrose 4-phosphate and D-xylulose 5-phosphate to form D-glyceraldehyde 3-phosphate and D-fructose 6-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).
Identifier: R-HSA-71324
Species: Homo sapiens
Compartment: cytosol
Cytosolic transketolase (TKT) catalyzes the reversible reaction of D-xylulose 5-phosphate and D-ribose 5-phosphate to form D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).
Identifier: R-HSA-163741
Species: Homo sapiens
Compartment: cytosol
Cytosolic transketolase (TKT) catalyzes the reversible reaction of D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to form D-xylulose 5-phosphate and D-ribose 5-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).
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