Reactome | MRN complex binds DNA double strand breaks

Schema > Reaction > Entries

MRN complex binds DNA double strand breaks Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10394677
displayName	MRN complex binds DNA double strand breaks
eventOf	[Pathway:R-BTA-2559586] DNA Damage/Telomere Stress Induced Senescence - Bos taurus [Pathway:R-BTA-5693548] Sensing of DNA Double Strand Breaks - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5693612] MRN complex bound to DNA ends recruits ATM - Bos taurus [Pathway:R-BTA-5685939] HDR through MMEJ (alt-NHEJ) - Bos taurus [Reaction:R-BTA-5687465] MRN complex binds RBBP8 - Bos taurus
inferredFrom	[Reaction:R-HSA-3785768] MRN complex binds DNA double strand breaks - Homo sapiens
input	[OtherEntity:R-ALL-75165] DNA double-strand break ends [nucleoplasm] [Complex:R-BTA-75164] MRN [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MRN complex binds DNA double strand breaks
output	[Complex:R-BTA-3785763] DNA DSBs:MRN [nucleoplasm]
precedingEvent	[Reaction:R-BTA-75174] Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-3785768
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-BTA-5693548] Sensing of DNA Double Strand Breaks
(precedingEvent)	[Pathway:R-BTA-5685939] HDR through MMEJ (alt-NHEJ) [Reaction:R-BTA-5687465] MRN complex binds RBBP8 [Reaction:R-BTA-5693612] MRN complex bound to DNA ends recruits ATM
(inferredTo)	[Reaction:R-HSA-3785768] MRN complex binds DNA double strand breaks