UniProt:Q6ZP29 SLC66A1

chain
  • chain:1-291
checksum B544D3BFA5458920
comment
  • FUNCTION Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.INTERACTION The di-leucine motif mediates lysosomal localization.MISCELLANEOUS May play a role in the export from lysosomes of cysteamine-cysteine mixed disulfide (MxD), the product formed upon treatment by cysteamine of patients with cystinosis, a disease characterized by the accumulation of cystine in the lysosomes.SIMILARITY Belongs to the laat-1 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 243742
description
  • recommendedName: fullName evidence="6"Lysosomal amino acid transporter 1 homolog alternativeName: PQ-loop repeat-containing protein 2 alternativeName: fullName evidence="8"Solute carrier family 66 member 1
displayName UniProt:Q6ZP29 SLC66A1
geneName
  • SLC66A1
  • PQLC2
identifier Q6ZP29
isSequenceChanged false
keyword
  • Alternative splicing
  • Amino-acid transport
  • Glycoprotein
  • Lysosome
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • SLC66A1
otherIdentifier
  • 11755451_x_at
  • 1555781_PM_at
  • 1555781_at
  • 1555783_3p_x_at
  • 1555783_PM_x_at
  • 1555783_x_at
  • 16660212
  • 2323604
  • 2323605
  • 2323606
  • 2323609
  • 2323610
  • 2323611
  • 2323612
  • 2323613
  • 2323614
  • 2323615
  • 2323617
  • 2323618
  • 2323619
  • 2323620
  • 2323621
  • 2323622
  • 2323623
  • 2323624
  • 2323625
  • 54896
  • 70129_r_at
  • 77384_at
  • 7898556
  • A_14_P104463
  • A_33_P3388491
  • GE82219
  • GO:0005290
  • GO:0005515
  • GO:0005764
  • GO:0005765
  • GO:0006865
  • GO:0015174
  • GO:0015189
  • GO:0015819
  • GO:0016020
  • GO:0031090
  • GO:0055085
  • GO:0061459
  • GO:0080144
  • GO:0089709
  • GO:1903401
  • GO:1903826
  • HMNXSV003028334
  • Hs2.263081.2.S1_3p_at
  • Hs2.263081.2.S1_3p_x_at
  • ILMN_2251664
  • ILMN_2330597
  • TC01000246.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • LAAT1_HUMAN
  • B3KWQ5
  • Q6ZMJ3
  • Q6ZP27
  • Q9NXC7
sequenceLength 291
species [Species:48887] Homo sapiens
stId uniprot:Q6ZP29
url http://purl.uniprot.org/uniprot/Q6ZP29
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