Graph Database :: Data Schema
Graph Database :: Data Schema
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DatabaseObject
- AbstractModifiedResidue [51759]
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Affiliation
[335]
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CatalystActivity
[37704]
- ControlReference [2729]
- ControlledVocabulary [14]
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DatabaseIdentifier
[720031]
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EntityFunctionalStatus
[683]
- Event [111908]
- ExternalOntology [958]
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Figure
[873]
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FunctionalStatus
[27]
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FunctionalStatusType
[5]
- GO_Term [3004]
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InstanceEdit
[124179]
- Interaction [54236]
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NegativePrecedingEvent
[313]
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Person
[156101]
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PhysicalEntity
[389298]
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Cell
[5]
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Complex
[101725]
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Drug
[1129]
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ChemicalDrug
[1038]
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ProteinDrug
[90]
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RNADrug
[1]
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ChemicalDrug
[1038]
- EntitySet [43152]
- GenomeEncodedEntity [237682]
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OtherEntity
[347]
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Polymer
[1504]
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SimpleEntity
[3754]
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Cell
[5]
- Publication [38727]
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ReferenceDatabase
[148]
- ReferenceEntity [739543]
- Regulation [6937]
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Summation
[20052]
- Taxon [391]
Entries: RegulationReference
| Identifier | Name |
|---|---|
| 9642964 | Negative gene expression regulation by '(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6):CDKN1A gene [nucleoplasm]' Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype |
| 9641570 | Negative gene expression regulation by '2x(p-STAT5A,p-STAT5B):BRWD1 gene [nucleoplasm]' Histone reader BRWD1 targets and restricts recombination to the Igk locus |
| 9657840 | Negative gene expression regulation by 'ABCA1 mRNA:miR-144 RISC [cytosol]' MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor |
| 9641820 | Negative gene expression regulation by 'ABCA1 mRNA:miR-26 RISC [cytosol]' MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7 |
| 9641516 | Negative gene expression regulation by 'ABCA1 mRNA:miR-33 RISC [cytosol]' MiR-33 contributes to the regulation of cholesterol homeostasis |
| 9858298 | Negative gene expression regulation by 'AXL3:MITF gene [nucleoplasm]' Developmental mechanisms of stripe patterns in rodents |
| 9858291 | Negative gene expression regulation by 'AXL3:MITF gene [nucleoplasm]' Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor |
| 9707518 | Negative gene expression regulation by 'BACH1:MAFK [nucleoplasm]' Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells |
| 9641613 | Negative gene expression regulation by 'CREM:PER1 gene [nucleoplasm]' Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks |
| 9641730 | Negative gene expression regulation by 'CRHR2:UCN(83-122) [plasma membrane]' Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors |
| 9851010 | Negative gene expression regulation by 'DNMT1 [nucleoplasm]' NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells |
| 9850959 | Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK |
| 9642802 | Negative gene expression regulation by 'DREAM complex:CDC25A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence |
| 9641835 | Negative gene expression regulation by 'DREAM complex:CDC6 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence |
| 9642011 | Negative gene expression regulation by 'DREAM complex:E2F1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence |
| 9642359 | Negative gene expression regulation by 'DREAM complex:PCNA gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence |
| 9641974 | Negative gene expression regulation by 'DREAM complex:RBL1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence |
| 9642902 | Negative gene expression regulation by 'DREAM complex:TOP2A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence |
| 9641265 | Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):APAF1 gene [nucleoplasm]' E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1 |
| 9643017 | Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):BRCA1 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9 |
| 9642627 | Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):CBX5 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9 |
| 9642014 | Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):RAD51 gene [nucleoplasm]' Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription |
| 9641954 | Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):RBBP4 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9 |
| 9641693 | Negative gene expression regulation by 'E2F6:(TFDP1.TFDP2):RBBP8 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9 |
| 9642139 | Negative gene expression regulation by 'E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm]' A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells |
| 9641666 | Negative gene expression regulation by 'E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]' E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression |
| 9642932 | Negative gene expression regulation by 'EGR2 [nucleoplasm]' PIASxbeta acts as an activator of Hoxb1 and is antagonized by Krox20 during hindbrain segmentation |
| 9642410 | Negative gene expression regulation by 'EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]' The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway |
| 9642854 | Negative gene expression regulation by 'ERBB4s80:TAB2:NCOR1:GFAP gene [nucleoplasm]' Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain |
| 9641839 | Negative gene expression regulation by 'ERBB4s80:TAB2:NCOR1:S100B gene [nucleoplasm]' Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain |
| 9642650 | Negative gene expression regulation by 'ERF:ETS2 Gene [nucleoplasm]' ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation |
| 9641582 | Negative gene expression regulation by 'ESR1:estrogen:AXIN1 gene [nucleoplasm]' RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer |
| 9643014 | Negative gene expression regulation by 'ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm]' Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform |
| 9831024 | Negative gene expression regulation by 'Foxc1 [nucleoplasm]' Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract |
| 9792548 | Negative gene expression regulation by 'Foxc1 [nucleoplasm]' The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate |
| 9831032 | Negative gene expression regulation by 'Foxc2 [nucleoplasm]' Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract |
| 9792552 | Negative gene expression regulation by 'Foxc2 [nucleoplasm]' The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate |
| 9833053 | Negative gene expression regulation by 'Gbx2:Otx2 gene [nucleoplasm]' A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer |
| 9642206 | Negative gene expression regulation by 'Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm]' Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis |
| 9642954 | Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CCNA2 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex |
| 9641640 | Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CDK1 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex |
| 9641575 | Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:E2F1 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex |
| 9641316 | Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:MYBL2 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex |
| 9825765 | Negative gene expression regulation by 'HINT1:MITF-M:BCL2 gene [nucleoplasm]' The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells |
| 9831397 | Negative gene expression regulation by 'HOXA6 [nucleoplasm]' Analysis of nephric duct specification in the avian embryo |
| 9642189 | Negative gene expression regulation by 'HOXB3 [nucleoplasm]' Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning |
| 9641427 | Negative gene expression regulation by 'Hdac1:Rbl2:E2f4,E2f5:Tfdp1,Tfdp2; Hdac1:Rbl1:E2f4:Tfdp1,Tfdp2:Ccna2 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex |
| 9641229 | Negative gene expression regulation by 'Hdac1:Rbl2:E2f4,E2f5:Tfdp1,Tfdp2; Hdac1:Rbl1:E2f4:Tfdp1,Tfdp2:Cdk1 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex |
| 9642989 | Negative gene expression regulation by 'Hdac1:Rbl2:E2f4,E2f5:Tfdp1,Tfdp2; Hdac1:Rbl1:E2f4:Tfdp1,Tfdp2:E2f1 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex |
| 9642204 | Negative gene expression regulation by 'Hdac1:Rbl2:E2f4,E2f5:Tfdp1,Tfdp2; Hdac1:Rbl1:E2f4:Tfdp1,Tfdp2:Mybl2 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex |
| 9824193 | Negative gene expression regulation by 'Hes7:Lef1:Ctnnb1:Tbx6:Rbpj:Nicd:Hes7 gene [nucleoplasm]' Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock |
| 9824251 | Negative gene expression regulation by 'Hes7:Rbpj:Nicd:Msgn1:Lfng gene [nucleoplasm]' Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock |
| 9641389 | Negative gene expression regulation by 'Ik1:Ptcra gene [nucleoplasm]' Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing |
| 9643022 | Negative gene expression regulation by 'JUN:PTEN gene [nucleoplasm]' Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras |
| 9642718 | Negative gene expression regulation by 'KSRP:mRNA Degradation Complex [cytosol]' IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR |
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