Reactome | RAB1B [cytosol]

RAB1B [cytosol]

Stable Identifier

R-CFA-5685727

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

A0A8I3NKE3

Locations in the PathwayBrowser

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Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPI-mediated anterograde transport (Canis familiaris)
        
        COPI vesicle uncoating (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        COPII-mediated vesicle transport (Canis familiaris)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        CSNK1D phosphorylates SEC23 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GTP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        Nucleotide exchange on RAB1 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GTP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GTP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GTP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
  - RAB geranylgeranylation (Canis familiaris)
    - RGGT geranylgeranylates RAB proteins (Canis familiaris)
      - RGGT:CHMs:RABs:GDP [cytosol] (Canis familiaris)
        
        RABs:GDP [cytosol] (Canis familiaris)
        
        RABs [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
    - RGGT:CHM binds RABs (Canis familiaris)
      - RABs:GDP [cytosol] (Canis familiaris)
        
        RABs [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
      - RGGT:CHMs:RABs:GDP [cytosol] (Canis familiaris)
        
        RABs:GDP [cytosol] (Canis familiaris)
        
        RABs [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - ER to Golgi Anterograde Transport (Canis familiaris)
    - COPI-mediated anterograde transport (Canis familiaris)
      - COPI vesicle uncoating (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
    - COPII-mediated vesicle transport (Canis familiaris)
      - COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
      - CSNK1D phosphorylates SEC23 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GTP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
      - Nucleotide exchange on RAB1 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GTP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GTP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)
        
        RAB1:GTP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
      - TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Canis familiaris)
    - Golgi-to-ER retrograde transport (Canis familiaris)
      - COPI-dependent Golgi-to-ER retrograde traffic (Canis familiaris)
        
        COPI vesicle uncoating at the ER (Canis familiaris)
        
        RAB1:GDP [cytosol] (Canis familiaris)
        
        RAB1 [cytosol] (Canis familiaris)
        
        RAB1B [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NKE3

Reference Genes

ENSEMBL:ENSCAFG00845011842.1

UCSC:A0A8I3NKE3

Other Identifiers

GO:0000045

GO:0003924

GO:0005525

GO:0006886

GO:0012505

GO:0016787

Participates

as a member of

RABs [cytosol] (Canis familiaris)

as a candidate of

RAB1 [cytosol] (Canis familiaris)

Other forms of this molecule

RAB1B [endoplasmic reticulum membrane]

GGC-RAB1B [transport vesicle membrane]

GGC-RAB1B [cytosol]

RAB1B [transport vesicle]

RAB1B [endoplasmic reticulum-Golgi intermediate compartment membrane]

RAB1B [Golgi membrane]

phospho-p-T191-RAB1B [Golgi membrane]

Inferred From

RAB1B [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFG00845011842, ENSCAFP00845016536, ENSCAFT00845021035

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