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MAP2K1 [cytosol]
Stable Identifier
R-DRE-59502
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
Q4V947
Locations in the PathwayBrowser
Expand all
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF-independent MAPK1/3 activation (Danio rerio)
MAPK3 (ERK1) activation (Danio rerio)
Inactivation of MAP2K1 by CDK1 (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
MAP2K and MAPK activation (Danio rerio)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPKs (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
RAF phosphorylates MAP2K dimer (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
Signalling to ERKs (Danio rerio)
Prolonged ERK activation events (Danio rerio)
Frs2-mediated activation (Danio rerio)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Danio rerio)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)
MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:Q4V947
Reference Genes
BioGPS Gene:406728
ENSEMBL:ENSDARG00000007825
KEGG:dre:406728
Monarch:406728
NCBI Gene:406728
UCSC:Q4V947
Reference Transcript
RefSeq:NM_213419.2
Participates
as a member of
MAP2K1 [cytosol] (Danio rerio)
as a component of
MAP2K1 dimer [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
Other forms of this molecule
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
phospho-p-T286,T292-MAP2K1 [cytosol]
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
phospho-p-S218,S222-MAP2K1 [cytosol]
Inferred From
MAP2K1 [cytosol]
(Homo sapiens)
Cross References
ZFIN
ZDB-GENE-040426-2759
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