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TREX1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-3244651
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Three prime repair exonuclease 1, 3'-5' exonuclease TREX1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
Regulation by TREX1 (Homo sapiens)
TREX1 binds retroviral-derived DNA (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
TREX1 [endoplasmic reticulum membrane] (Homo sapiens)
TREX1:viral DNA [endoplasmic reticulum membrane] (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
TREX1 [endoplasmic reticulum membrane] (Homo sapiens)
Viral DNA cleavage by TREX1 (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
TREX1 [endoplasmic reticulum membrane] (Homo sapiens)
TREX1:viral DNA [endoplasmic reticulum membrane] (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
TREX1 [endoplasmic reticulum membrane] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
STING recruits TBK1 and IRF3 (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
TREX1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NSU2 TREX1
Gene Names
TREX1
Chain
chain:1-314
Reference Genes
BioGPS Gene:11277 TREX1
COSMIC - genes:TREX1 TREX1
CTD Gene:11277 TREX1
dbSNP Gene:11277 TREX1
ENSEMBL:ENSG00000213689 TREX1
HGNC:12269 TREX1
KEGG:hsa:11277 TREX1
Monarch:11277 TREX1
NCBI Gene:11277 TREX1
OMIM:606609 TREX1
UCSC:Q9NSU2 TREX1
Reference Transcript
RefSeq:NM_033629.6 TREX1
RefSeq:NM_007248.3 TREX1
Participates
as a component of
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Cross References
RefSeq
NP_009179.2
,
NP_338599.1
ENSEMBL
ENSG00000213689
,
ENST00000625293
,
ENSP00000486676
,
ENST00000444177
,
ENSP00000415972
OpenTargets
ENSG00000213689
GeneCards
TREX1
HPA
ENSG00000213689-TREX1
PRO
Q9NSU2
Pharos - Targets
Q9NSU2
Orphanet
TREX1
HMDB Protein
HMDBP08827
PDB
7TQP
,
9O0W
,
9O0Y
,
9O0X
,
7TQO
,
7TQN
,
9AVA
,
8VL7
,
7TQQ
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