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SLC6A4 [plasma membrane]
Stable Identifier
R-HSA-444015
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SERT, Sodium-dependent serotonin transporter, SC6A4_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Serotonin clearance from the synaptic cleft (Homo sapiens)
SLC6A4 binds TCAs and SSRIs (Homo sapiens)
SLC6A4 [plasma membrane] (Homo sapiens)
SLC6A4:TCAs and SSRIs [plasma membrane] (Homo sapiens)
SLC6A4 [plasma membrane] (Homo sapiens)
SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)
SLC6A4 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
SLC-mediated transport of neurotransmitters (Homo sapiens)
Reuptake of serotonin from the synapse (Homo sapiens)
SLC6A4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31645 SLC6A4
Gene Names
SLC6A4, HTT, SERT
Chain
chain:1-630
Reference Genes
BioGPS Gene:6532 SLC6A4
COSMIC - genes:HTT HTT
COSMIC - genes:SLC6A4 SLC6A4
CTD Gene:6532 SLC6A4
dbSNP Gene:6532 SLC6A4
ENSEMBL:ENSG00000108576 SLC6A4
HGNC:11050 SLC6A4
KEGG:hsa:6532 SLC6A4
Monarch:6532 SLC6A4
NCBI Gene:6532 SLC6A4
OMIM:182138 SLC6A4
UCSC:P31645 SLC6A4
Reference Transcript
RefSeq:NM_001045.6 SLC6A4
Other Identifiers
11734147_a_at
11734148_at
16843078
207519_PM_at
207519_at
241811_3p_x_at
241811_PM_x_at
241811_x_at
242009_PM_at
242009_at
34604_at
3751787
3751789
3751790
3751791
3751792
3751793
3751795
3751796
3751797
3751798
3751799
3751804
3751809
3751810
3751811
3751813
3751814
3751815
3751816
3751817
3751818
3751819
3751820
3751823
3751824
3751825
3751826
3751829
53297_r_at
6532
75016_at
8013989
A_23_P152995
A_32_P182812
GE527131
GE80977
GE88093
GO:0001666
GO:0003013
GO:0005178
GO:0005261
GO:0005326
GO:0005335
GO:0005515
GO:0005768
GO:0005886
GO:0005925
GO:0006836
GO:0006837
GO:0006865
GO:0007584
GO:0007613
GO:0007623
GO:0008092
GO:0008504
GO:0009410
GO:0009636
GO:0010008
GO:0010628
GO:0012505
GO:0014064
GO:0015297
GO:0015844
GO:0016020
GO:0017075
GO:0019811
GO:0021941
GO:0022414
GO:0022857
GO:0031402
GO:0032227
GO:0032355
GO:0035725
GO:0042310
GO:0042734
GO:0042802
GO:0042995
GO:0043005
GO:0045121
GO:0045202
GO:0045211
GO:0045665
GO:0045787
GO:0046621
GO:0046872
GO:0048148
GO:0048484
GO:0048854
GO:0048856
GO:0050877
GO:0050998
GO:0051015
GO:0051378
GO:0051610
GO:0051899
GO:0055085
GO:0060179
GO:0070161
GO:0070527
GO:0071300
GO:0071321
GO:0090067
GO:0098793
GO:0098810
GO:0099154
GO:1990708
HMNXSV003016963
Hs.134662.0.A1_3p_at
Hs.29792.0.A1_3p_at
Hs.29792.0.A1_3p_x_at
ILMN_1683694
ILMN_1869934
L05568_at
PH_hs_0002572
PH_hs_0008106
PH_hs_0026202
TC17001326.hg
g4507042_3p_at
Participates
as a component of
SLC6A4:TCAs and SSRIs [plasma membrane] (Homo sapiens)
as an input of
SLC6A4 binds TCAs and SSRIs (Homo sapiens)
Inferred To
Homologues of SLC6A4 [plasma membrane]
(Plasmodium falciparum)
SLC6A4 [plasma membrane]
(Bos taurus)
SLC6A4 [plasma membrane]
(Caenorhabditis elegans)
SLC6A4 [plasma membrane]
(Canis familiaris)
SLC6A4 [plasma membrane]
(Danio rerio)
SLC6A4 [plasma membrane]
(Drosophila melanogaster)
SLC6A4 [plasma membrane]
(Gallus gallus)
SLC6A4 [plasma membrane]
(Mus musculus)
SLC6A4 [plasma membrane]
(Plasmodium falciparum)
SLC6A4 [plasma membrane]
(Rattus norvegicus)
SLC6A4 [plasma membrane]
(Sus scrofa)
SLC6A4 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001036.1
ZINC - World Drugs
SC6A4_HUMAN
Guide to Pharmacology - Targets
928
OpenTargets
ENSG00000108576
ENSEMBL
ENST00000650711
,
ENSG00000108576
,
ENSP00000498537
,
ENSP00000261707
,
ENSP00000385822
,
ENST00000401766
,
ENST00000261707
ZINC - FDA approved
SC6A4_HUMAN
ZINC - Substances
SC6A4_HUMAN
ZINC - Biogenic
SC6A4_HUMAN
ZINC target
P31645
PRO
P31645
GlyGen
P31645
PDB
6AWO
,
6AWN
,
6AWQ
,
7MGW
,
6AWP
,
6W2B
,
5I75
,
6VRK
,
5I71
,
7LI9
,
5I6Z
,
6DZY
,
6VRL
,
6VRH
,
6DZZ
,
7LIA
,
5I6X
,
6W2C
,
7TXT
,
7LWD
,
7LI6
,
7LI8
,
7LI7
,
5I73
,
5I74
,
6DZW
,
6DZV
ZINC - Investigational
SC6A4_HUMAN
ZINC - Metabolites
SC6A4_HUMAN
HPA
ENSG00000108576-SLC6A4
GeneCards
SLC6A4
Pharos - Targets
P31645
ZINC - Predictions - Purchasable
SC6A4_HUMAN
HMDB Protein
HMDBP02165
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35803 GPM6B
0.463
2
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