Expression of NDN,TP53

Stable Identifier
R-HSA-6789960
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of NDN,TP53
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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of gene expression in response to signaling of many cytokines including interleukin-6 (IL6), Oncostatin M, and leukemia inhibitory factor. Using microarray techniques, hundreds of genes have been reported as potential STAT3 target genes (Dauer et al. 2005, Hsieh et al. 2005). Some of these genes have been proven to be direct STAT3 targets using genome-wide chromatin immunoprecipitation screening (Snyder et al. 2008, Carpenter & Lo 2014). Genes encoding nuclear proteins that are downregulated by STAT3 include Necdin (NDN) (Haviland et al. 2011) and Cellular tumor antigen p53 (TP53) (Niu et al. 2005).
Literature References
PubMed ID Title Journal Year
16107692 Role of Stat3 in regulating p53 expression and function

Niu, G, Wright, KL, Ma, Y, Wright, GM, Huang, M, Irby, R, Briggs, J, Karras, J, Cress, WD, Pardoll, D, Jove, R, Chen, J, Yu, H

Mol. Cell. Biol. 2005
22046235 Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer

Haviland, R, Eschrich, S, Bloom, G, Ma, Y, Minton, S, Jove, R, Cress, WD

PLoS ONE 2011
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Output
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as an event of
This event is regulated
Negatively by
Regulator
p-Y705-STAT3 dimer [nucleoplasm] (Homo sapiens)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-08-06)
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