Reactome | ALPK1 [cytosol]

ALPK1 [cytosol]

Stable Identifier

R-HSA-9645473

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Alpha-protein kinase 1

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Alpha-protein kinase 1 signaling pathway (Homo sapiens)
    - ALPK1 binds ADP-heptose (Homo sapiens)
      - ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - ALPK1 phosphorylates TIFA (Homo sapiens)
      - ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:TIFA dimer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - ALPK1:ADP-heptose binds TIFA (Homo sapiens)
      - ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:TIFA dimer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - TIFA oligomerization (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Homo sapiens)
        
        ALPK1:ADP heptose [cytosol] (Homo sapiens)
        
        ALPK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96QP1 ALPK1

Gene Names

ALPK1, KIAA1527, LAK

Chain

chain:1-1244

Reference Genes

BioGPS Gene:80216 ALPK1

COSMIC - genes:ALPK1 ALPK1

CTD Gene:80216 ALPK1

dbSNP Gene:80216 ALPK1

ENSEMBL:ENSG00000073331 ALPK1

HGNC:20917 ALPK1

KEGG:hsa:80216 ALPK1

Monarch:80216 ALPK1

NCBI Gene:80216 ALPK1

OMIM:607347 ALPK1

UCSC:Q96QP1 ALPK1

Reference Transcript

Other Identifiers

11730576_a_at

11750489_a_at

11761945_at

16969839

207133_3p_x_at

207133_PM_x_at

207133_x_at

227438_PM_at

227438_at

243222_PM_at

243222_at

2739793

2739794

2739798

2739800

2739804

2739805

2739806

2739807

2739808

2739809

2739811

2739812

2739813

2739814

2739815

2739829

2739830

2739831

2739832

2739833

2739834

2739840

2739841

2739843

2739844

2739845

2739846

2739847

2739848

2739849

2739850

2739851

2739855

2739856

2739857

2739858

2739859

2739861

2739863

2739864

2739865

2739866

2739868

2739869

2739870

2739871

2739872

47592_at

80216

8096919

86881_at

90698_at

A_23_P133133

A_23_P133142

A_23_P144531

GE61862

GE629152

GO:0000922

GO:0002376

GO:0002753

GO:0003824

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0006468

GO:0016301

GO:0016740

GO:0030030

GO:0036064

GO:0042995

GO:0043123

GO:0043226

GO:0044782

GO:0045087

GO:0048029

GO:0060271

GO:0098542

GO:0106310

GO:0140096

HMNXSV003015703

HMNXSV003027994

HMNXSV003053599

Hs.130417.0.A1_3p_at

Hs.193671.0.A1_3p_at

Hs.96840.0.S1_3p_at

ILMN_2078697

PH_hs_0004129

PH_hs_0026851

g13376730_3p_x_at

Participates

as an input of

ALPK1 binds ADP-heptose (Homo sapiens)

as a component of

ALPK1:ADP heptose [cytosol] (Homo sapiens)

Inferred To

Alpk1 [cytosol] (Rattus norvegicus)

ALPK1 [cytosol] (Bos taurus)

ALPK1 [cytosol] (Canis familiaris)

ALPK1 [cytosol] (Gallus gallus)

ALPK1 [cytosol] (Mus musculus)

ALPK1 [cytosol] (Sus scrofa)

alpk1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001240813.1, NP_079420.3, NP_001095876.1

Guide to Pharmacology - Targets

1930

ENSEMBL

ENSP00000398048, ENST00000504176, ENSP00000177648, ENST00000177648, ENST00000458497, ENSP00000498374, ENSG00000073331, ENST00000650871, ENSP00000426044

OpenTargets

ENSG00000073331

IntEnz

2.7.11.1

GeneCards

ALPK1

HPA

ENSG00000073331-ALPK1

PRO

Q96QP1

Pharos - Targets

Q96QP1

PDB

8ZD3, 5Z2C

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