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ASB10 [cytosol]
Stable Identifier
R-HSA-975417
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ankyrin repeat and SOCS box protein 10, ASB10_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL5-box protein [cytosol] (Homo sapiens)
ASB10 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WXI3 ASB10
Gene Names
ASB10
Chain
chain:1-467
Reference Genes
BioGPS Gene:136371 ASB10
COSMIC (genes):ASB10 ASB10
CTD Gene:136371 ASB10
dbSNP Gene:136371 ASB10
ENSEMBL:ENSG00000146926 ASB10
ENSEMBL_homo_sapiens_GENE:ENSG00000146926.11 ASB10
HGNC:17185 ASB10
KEGG Gene (Homo sapiens):136371 ASB10
Monarch:136371 ASB10
NCBI Gene:136371 ASB10
OMIM:615054 ASB10
UCSC:Q8WXI3 ASB10
Reference Transcript
RefSeq:NM_080871.3 ASB10
RefSeq:NM_001142459.1 ASB10
RefSeq:NM_001142460.1 ASB10
Other Identifiers
11739760_a_at
11741584_a_at
136371
1553039_PM_a_at
1553039_a_at
1564536_PM_at
1564536_at
1564537_PM_a_at
1564537_a_at
17064424
3079439
3079440
3079442
3079443
3079444
3079445
3079447
3079449
3079450
3079451
3079452
3079453
3079454
3079455
3079456
8143887
A_23_P427634
A_33_P3290124
GE525397
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0016567
GO:0023052
GO:0035556
GO:0036211
GO:0043226
HMNXSV003007071
HMNXSV003027958
Hs2.304273.2.S1_3p_s_at
ILMN_1781148
PH_hs_0015687
TC07002032.hg
Participates
as a member of
CUL5-box protein [cytosol] (Homo sapiens)
ASB family [cytosol] (Homo sapiens)
Inferred To
Homologues of ASB10 [cytosol]
(Caenorhabditis elegans)
Homologues of ASB10 [cytosol]
(Saccharomyces cerevisiae)
Asb10 [cytosol]
(Mus musculus)
PHO81 [cytosol]
(Saccharomyces cerevisiae)
caiap [cytosol]
(Danio rerio)
Ank2 [cytosol]
(Drosophila melanogaster)
HOS4 [cytosol]
(Saccharomyces cerevisiae)
mask-1 [cytosol]
(Caenorhabditis elegans)
unc-44 [cytosol]
(Caenorhabditis elegans)
ASB10 [cytosol]
(Bos taurus)
ASB10 [cytosol]
(Sus scrofa)
cnrM [cytosol]
(Dictyostelium discoideum)
asb15 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_543147.2
,
NP_001135931.2
,
NP_001135932.2
OpenTargets
ENSG00000146926
GeneCards
Q8WXI3
HPA
ENSG00000146926-ASB10
Ensembl
ENSP00000391137
,
ENST00000275838
,
ENST00000377867
,
ENSP00000275838
,
ENSP00000367098
,
ENSG00000146926
,
ENST00000420175
PRO
Q8WXI3
Pharos - Targets
Q8WXI3
Orphanet
22234
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