Reactome | KCND2 [plasma membrane]

KCND2 [plasma membrane]

Stable Identifier

R-HSA-977453

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily D member 2, KCND2_HUMAN

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        KCND1,2,3 [plasma membrane] (Homo sapiens)
        
        KCND2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NZV8 KCND2

Gene Names

KCND2, KIAA1044

Chain

chain:1-630

Reference Genes

BioGPS Gene:3751 KCND2

COSMIC (genes):KCND2 KCND2

CTD Gene:3751 KCND2

dbSNP Gene:3751 KCND2

ENSEMBL:ENSG00000184408 KCND2

HGNC:6238 KCND2

KEGG:hsa:3751 KCND2

Monarch:3751 KCND2

NCBI Gene:3751 KCND2

OMIM:605410 KCND2

UCSC:Q9NZV8 KCND2

Reference Transcript

Other Identifiers

11736529_at

11736530_at

17050765

207103_PM_at

207103_at

3021002

3021004

3021006

3021008

3021010

3021011

3021012

3021055

3021056

3021057

3021058

3021059

3021060

32873_at

3751

8135705

A_14_P111263

A_14_P201598

A_23_P259251

GE62462

GO:0001508

GO:0003012

GO:0005215

GO:0005216

GO:0005249

GO:0005250

GO:0005267

GO:0005515

GO:0005886

GO:0006811

GO:0006813

GO:0006936

GO:0007268

GO:0008016

GO:0008076

GO:0016020

GO:0019228

GO:0019233

GO:0023052

GO:0030425

GO:0032809

GO:0034702

GO:0042995

GO:0043025

GO:0043197

GO:0043204

GO:0044853

GO:0045202

GO:0045211

GO:0045475

GO:0046872

GO:0050877

GO:0051260

GO:0055085

GO:0060078

GO:0065003

GO:0070161

GO:0071193

GO:0071456

GO:0071805

GO:0086009

GO:0098978

GO:0098982

GO:0099634

GO:1905030

HMNXSV003009680

ILMN_1748755

PH_hs_0011940

PH_hs_0012390

TC07000732.hg

g9789986_3p_at

Participates

as a member of

KCND1,2,3 [plasma membrane] (Homo sapiens)

Inferred To

kcnd2 [plasma membrane] (Danio rerio)

kcnd2 [plasma membrane] (Xenopus tropicalis)

shl-1 [plasma membrane] (Caenorhabditis elegans)

Shal [plasma membrane] (Drosophila melanogaster)

Kcnd2 [plasma membrane] (Mus musculus)

Kcnd2 [plasma membrane] (Rattus norvegicus)

KCND2 [plasma membrane] (Bos taurus)

KCND2 [plasma membrane] (Canis familiaris)

KCND2 [plasma membrane] (Gallus gallus)

KCND2 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_047276302.1, XP_054214141.1, NP_036413.1

Guide to Pharmacology - Targets

553

ENSEMBL

ENST00000331113, ENSG00000184408, ENSP00000333496

OpenTargets

ENSG00000184408

GeneCards

KCND2

HPA

ENSG00000184408-KCND2

PRO

Q9NZV8

Pharos - Targets

Q9NZV8

HMDB Protein

HMDBP10843

PDB

7UKD, 7UKF, 7UKC, 7UKH, 7UKE, 7E8E, 7E8B, 7UKG, 7E87, 7E7Z, 7F0J, 7UK5, 7E83, 7E84, 7F3F, 7E8H

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2