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About
What is Reactome ?
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HGS [cytosol]
Stable Identifier
R-RNO-182954
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q9JJ50
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
USP8 deubiquitinates STAM2:HGS (Rattus norvegicus)
USP8:STAM2:HGS [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
USP8:Ub-STAM2:HGS [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by EGFR (Rattus norvegicus)
EGFR downregulation (Rattus norvegicus)
CBL-mediated ubiquitination of CIN85 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
EGFR binds EPS15, EPN1, EPS15L1 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
EGFR non-clathrin mediated endocytosis (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
EGFR phosphorylates EPS15 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PTPN3 dephosphorylates EPS15 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Sprouty sequesters CBL away from active EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
Negative regulation of MET activity (Rattus norvegicus)
EPS15 and HGS bind ubiquitinated MET (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Rattus norvegicus)
EPS15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Clathrin-mediated endocytosis (Rattus norvegicus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
BAR domain proteins recruit dynamin (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Clathrin recruits PIK3C2A (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Dissociation of clathrin-associated proteins (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
SNX9 recruits components of the actin polymerizing machinery (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
p-Eps15:HGS:STAM [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
Endosomal Sorting Complex Required For Transport (ESCRT) (Rattus norvegicus)
Cargo Recognition And Sorting (Rattus norvegicus)
ESCRT-0 [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
ESCRT-0/Cargo Complex [endosome membrane] (Rattus norvegicus)
ESCRT-0 [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
trans-Golgi Network Vesicle Budding (Rattus norvegicus)
Lysosome Vesicle Biogenesis (Rattus norvegicus)
AP1G2 binds HGS and CHMP2A (Rattus norvegicus)
AP1G2:HGS:CHMP2A [Golgi membrane] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
HGS [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9JJ50
Reference Genes
BioGPS Gene:56084
ENSEMBL:ENSRNOG00000036696
KEGG Gene (Rattus norvegicus):56084
Monarch:56084
NCBI Gene:56084
Reference Transcript
RefSeq:NM_019387.2
Participant Of
hasComponent
AP1G2:HGS:CHMP2A [Golgi membrane]
EPS15:HGS:STAM [cytosol]
ESCRT-0 [cytosol]
p-Eps15:HGS:STAM [cytosol]
USP8:STAM2:HGS [cytosol]
USP8:Ub-STAM2:HGS [cytosol]
input
AP1G2 binds HGS and CHMP2A
Inferred From
HGS [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_062260.2
PRO
Q9JJ50
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42566 EPS15
2
EPS15 [cytosol]
(R-HSA-182920)
p-Y850 EPS15 [cytosol]
(R-HSA-8867028)
0.72
5
UniProt:P54256 HAP1
0.611
5
UniProt:P54256-2 HAP1
0.599
5
UniProt:P60881
3
SNAP25 [plasma membrane]
(R-RNO-2029017)
SNAP25 [specific granule membrane]
(R-RNO-6806154)
SNAP25 [tertiary granule membrane]
(R-RNO-6806142)
0.527
2
UniProt:P54256-1 HAP1
0.462
2
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