Marija Orlic-Milacic

Orcid ID
Ontario Institute for Cancer Research
Authored (261)
Identifier Pathway
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-9032845 Activated NTRK2 signals through CDK5
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9032500 Activated NTRK2 signals through FYN
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9603381 Activated NTRK3 signals through PI3K
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-HSA-9024909 BDNF activates NTRK2 (TRKB) signaling
R-HSA-73884 Base Excision Repair
R-HSA-2559583 Cellular Senescence
R-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin
R-HSA-2470946 Cohesin Loading onto Chromatin
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-73893 DNA Damage Bypass
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-4419969 Depolymerisation of the Nuclear Lamina
R-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling
R-HSA-1253288 Downregulation of ERBB4 signaling
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-8847993 ERBB2 Activates PTK6 Signaling
R-HSA-6785631 ERBB2 Regulates Cell Motility
R-HSA-2468052 Establishment of Sister Chromatid Cohesion
R-HSA-9036866 Expression and Processing of Neurotrophins
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-2644605 FBXW7 Mutants and NOTCH1 in Cancer
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-1538133 G0 and Early G1
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-1306955 GRB7 events in ERBB2 signaling
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5685939 HDR through MMEJ (alt-NHEJ)
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693538 Homology Directed Repair
R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR
R-HSA-2995383 Initiation of Nuclear Envelope Reformation
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8854521 Interaction between PHLDA1 and AURKA
R-HSA-8876384 Listeria monocytogenes entry into host cells
R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer
R-HSA-3304347 Loss of Function of SMAD4 in Cancer
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer
R-HSA-3642278 Loss of Function of TGFBR2 in Cancer
R-HSA-2465910 MASTL Facilitates Mitotic Progression
R-HSA-6806942 MET Receptor Activation
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8865999 MET activates PTPN11
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8851805 MET activates RAS signaling
R-HSA-8875791 MET activates STAT3
R-HSA-8875513 MET interacts with TNS proteins
R-HSA-8875878 MET promotes cell motility
R-HSA-8875656 MET receptor recycling
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
R-HSA-9025046 NTF3 activates NTRK2 (TRKB) signaling
R-HSA-9034013 NTF3 activates NTRK3 signaling
R-HSA-9026357 NTF4 activates NTRK2 (TRKB) signaling
R-HSA-9032759 NTRK2 activates RAC1
R-HSA-9603505 NTRK3 as a dependence receptor
R-HSA-6807004 Negative regulation of MET activity
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8863678 Neurodegenerative Diseases
R-HSA-9017802 Noncanonical activation of NOTCH3
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-2995410 Nuclear Envelope Reassembly
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-1963642 PI3K events in ERBB2 signaling
R-HSA-1250342 PI3K events in ERBB4 signaling
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1251932 PLCG1 events in ERBB2 signaling
R-HSA-5674404 PTEN Loss of Function in Cancer
R-HSA-6807070 PTEN Regulation
R-HSA-8849474 PTK6 Activates STAT3
R-HSA-8849472 PTK6 Down-Regulation
R-HSA-8849473 PTK6 Expression
R-HSA-8849470 PTK6 Regulates Cell Cycle
R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-HSA-8857538 PTK6 promotes HIF1A stabilization
R-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-195258 RHO GTPase Effectors
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5627083 RHO GTPases regulate CFTR trafficking
R-HSA-9010642 ROBO receptors bind AKAP5
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
R-HSA-8941326 RUNX2 regulates bone development
R-HSA-8941284 RUNX2 regulates chondrocyte maturation
R-HSA-8941332 RUNX2 regulates genes involved in cell migration
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription
R-HSA-8941855 RUNX3 regulates CDKN1A transcription
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription
R-HSA-8951430 RUNX3 regulates WNT signaling
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
R-HSA-8951936 RUNX3 regulates p14-ARF
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8948747 Regulation of PTEN localization
R-HSA-8943723 Regulation of PTEN mRNA translation
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8934593 Regulation of RUNX1 Expression and Activity
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors
R-HSA-6804760 Regulation of TP53 Activity through Methylation
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6804754 Regulation of TP53 Expression
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-8985801 Regulation of cortical dendrite branching
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-5693537 Resolution of D-Loop Structures
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity
R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-3311021 SMAD4 MH2 Domain Mutants in Cancer
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-162582 Signal Transduction
R-HSA-1643713 Signaling by EGFR in Cancer
R-HSA-5637812 Signaling by EGFRvIII in Cancer
R-HSA-1227986 Signaling by ERBB2
R-HSA-1236394 Signaling by ERBB4
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-6806834 Signaling by MET
R-HSA-1980143 Signaling by NOTCH1
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
R-HSA-9012852 Signaling by NOTCH3
R-HSA-9013694 Signaling by NOTCH4
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer
R-HSA-8848021 Signaling by PTK6
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer
R-HSA-8847453 Synthesis of PIPs in the nucleus
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-3656532 TGFBR1 KD Mutants in Cancer
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer
R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer
R-HSA-3642279 TGFBR2 MSI Frameshift Mutants in Cancer
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-8953750 Transcriptional Regulation by E2F6
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-5656121 Translesion synthesis by POLI
R-HSA-5655862 Translesion synthesis by POLK