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APOA1 [extracellular region]
Stable Identifier
R-CFA-174720
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
APOA1(25-266), A0A8I3MSG4
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Heme signaling (Canis familiaris)
FeHM oxidises LDL,HDL (Canis familiaris)
LDL,HDL [extracellular region] (Canis familiaris)
discoidal HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
oxidized LDL,HDL [extracellular region] (Canis familiaris)
oxidized discoidal HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
oxidized spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
Release of platelet secretory granule components (Canis familiaris)
Platelet releasate secretory granule proteins [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Metabolism (Canis familiaris)
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of fat-soluble vitamins (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
CR:atREs binds apoE and HSPG (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
CR:atREs:HSPG:apoE [plasma membrane] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Cytosolic CMs translocate to extracellular region (Canis familiaris)
nascent CM:atREs [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
LPL hydrolyses TGs from mature CMs (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)
CR:atREs:HSPG:apoE [plasma membrane] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Nascent CMs transform into mature CMs (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
nascent CM:atREs [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
CR:atREs binds apoE and HSPG (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
CR:atREs:HSPG:apoE [plasma membrane] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Cytosolic CMs translocate to extracellular region (Canis familiaris)
nascent CM:atREs [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
LPL hydrolyses TGs from mature CMs (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)
CR:atREs:HSPG:apoE [plasma membrane] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Nascent CMs transform into mature CMs (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
nascent CM:atREs [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Transport of small molecules (Canis familiaris)
Plasma lipoprotein assembly, remodeling, and clearance (Canis familiaris)
Plasma lipoprotein assembly (Canis familiaris)
Chylomicron assembly (Canis familiaris)
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron (Canis familiaris)
chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
nascent chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Canis familiaris)
nascent chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
HDL assembly (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
discoidal HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)
discoidal HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
pre-beta HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Plasma lipoprotein clearance (Canis familiaris)
HDL clearance (Canis familiaris)
Disassembly of SR-BI-bound spherical HDL (Canis familiaris)
pre-beta HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
HDLBP binds HDL (Canis familiaris)
HDLBP:HDL [plasma membrane] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL and SR-BI receptor form a complex at the cell surface (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Plasma lipoprotein remodeling (Canis familiaris)
Chylomicron remodeling (Canis familiaris)
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
chylomicron [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
HDL remodeling (Canis familiaris)
Discoidal HDL binds membrane-associated free cholesterol (Canis familiaris)
discoidal HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
discoidal HDL:cholesterol [extracellular region] (Canis familiaris)
discoidal HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Spherical HDL binds C and E apolipoproteins (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Spherical HDL binds membrane-associated free cholesterol and phospholipids (Canis familiaris)
enlarged spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Binding and Uptake of Ligands by Scavenger Receptors (Canis familiaris)
Scavenging by Class A Receptors (Canis familiaris)
MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Canis familiaris)
MSR1:Ligand [plasma membrane] (Canis familiaris)
Ligands of MSR1 [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
Scavenging by Class B Receptors (Canis familiaris)
Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Canis familiaris)
Platelet glycoprotein IV:Ligand [plasma membrane] (Canis familiaris)
Ligands of CD36 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
SCARB1 (SR-BI, CLA-1) binds ligands (Canis familiaris)
Ligands of SCARB1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
SCARB1:Ligand [plasma membrane] (Canis familiaris)
Ligands of SCARB1 [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
APOA1 [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MSG4
Gene Names
APOA1
Reference Genes
BioGPS Gene:479427 APOA1
ENSEMBL:ENSCAFG00845004266.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845004266.1 APOA1
KEGG Gene (Canis lupus familiaris):479427 APOA1
Monarch:479427 APOA1
NCBI Gene:479427 APOA1
Reference Transcript
RefSeq:XM_014113398.1 APOA1
Other Identifiers
479427
CfaAffx.20609.1.S1_at
GO:0001540
GO:0001932
GO:0001935
GO:0002376
GO:0002719
GO:0005102
GO:0005215
GO:0005319
GO:0005543
GO:0005576
GO:0005615
GO:0006629
GO:0006644
GO:0006656
GO:0006695
GO:0006869
GO:0006954
GO:0007010
GO:0007155
GO:0007186
GO:0007229
GO:0008035
GO:0008203
GO:0008211
GO:0008289
GO:0010804
GO:0010875
GO:0010903
GO:0015485
GO:0016192
GO:0019899
GO:0019915
GO:0022600
GO:0023052
GO:0030139
GO:0030300
GO:0030301
GO:0030325
GO:0031072
GO:0031410
GO:0032489
GO:0032691
GO:0033344
GO:0033700
GO:0034115
GO:0034190
GO:0034191
GO:0034361
GO:0034364
GO:0034366
GO:0034375
GO:0034380
GO:0035025
GO:0036211
GO:0042157
GO:0042158
GO:0042632
GO:0042802
GO:0043226
GO:0043534
GO:0043691
GO:0045499
GO:0048018
GO:0048856
GO:0048870
GO:0050728
GO:0050766
GO:0050821
GO:0050919
GO:0051180
GO:0051496
GO:0055091
GO:0060228
GO:0060354
GO:0060761
GO:0061024
GO:0065003
GO:0070328
GO:0070508
GO:0070653
GO:0071813
GO:0090205
GO:0098772
GO:0120009
GO:0120020
GO:1900026
GO:1902995
Participates
as a member of
Platelet releasate secretory granule proteins [extracellular region] (Canis familiaris)
Ligands of MSR1 [extracellular region] (Canis familiaris)
as a component of
nascent CM:atREs [extracellular region] (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
enlarged spherical HDL [extracellular region] (Canis familiaris)
chylomicron [extracellular region] (Canis familiaris)
nascent chylomicron [extracellular region] (Canis familiaris)
pre-beta HDL [extracellular region] (Canis familiaris)
oxidized spherical HDL [extracellular region] (Canis familiaris)
oxidized discoidal HDL [extracellular region] (Canis familiaris)
discoidal HDL [extracellular region] (Canis familiaris)
spherical HDL [extracellular region] (Canis familiaris)
as an input of
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Canis familiaris)
as an output of
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Canis familiaris)
Other forms of this molecule
APOA1 [secretory granule lumen]
APOA1 [cytosol]
APOA1 [early endosome]
APOA1 [endoplasmic reticulum lumen]
APOA1 [extracellular region]
APOA1 [plasma membrane]
APOA1 [endocytic vesicle lumen]
phospho-APOA1 [endoplasmic reticulum lumen]
APOA1 [endoplasmic reticulum lumen]
Inferred From
APOA1(25-266) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_013968873.1
OpenTargets
ENSG00000118137
Ensembl
ENSCAFP00845006071
,
ENSCAFG00845004266
,
ENSCAFT00845007678
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