Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
run [nucleoplasm]
Stable Identifier
R-DME-8865393
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
RUNX3, P22814
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX3 (Drosophila melanogaster)
RUNX3 regulates CDKN1A transcription (Drosophila melanogaster)
RUNX3 binds SMAD3 and SMAD4 (Drosophila melanogaster)
RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
RUNX3 binds TP53 (Drosophila melanogaster)
RUNX3:TP53 tetramer [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
RUNX3 binds ZFHX3 (Drosophila melanogaster)
RUNX3:ZFHX3 [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
RUNX3 regulates WNT signaling (Drosophila melanogaster)
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Drosophila melanogaster)
RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
RUNX3 regulates YAP1-mediated transcription (Drosophila melanogaster)
RUNX3 binds TEADs and YAP1 (Drosophila melanogaster)
RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
RUNX3 regulates p14-ARF (Drosophila melanogaster)
EP300 acetylates RUNX3 (Drosophila melanogaster)
RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
RUNX3:CBFB [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
HDAC4 deacetylates RUNX3 (Drosophila melanogaster)
RUNX3:CBFB:CCND1:HDAC4 [nucleoplasm] (Drosophila melanogaster)
RUNX3:CBFB [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
RUNX3 binds EP300 (Drosophila melanogaster)
RUNX3:CBFB [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
RUNX3:CBFB:EP300 [nucleoplasm] (Drosophila melanogaster)
RUNX3:CBFB [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
Regulation of RUNX3 expression and activity (Drosophila melanogaster)
CBFB binds RUNX3 (Drosophila melanogaster)
RUNX3:CBFB [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
RUNX3 translocates to the nucleus (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)
run [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P22814
Gene Names
run
Reference Genes
BioGPS Gene:33059 run
CTD Gene:33059 run
ENSEMBL:FBgn0003300
FlyBase:FBgn0003300
KEGG:dme:Dmel_CG1849 run
Monarch:33059 run
NCBI Gene:33059 run
UCSC:P22814 run
Reference Transcript
RefSeq:NM_001298572.1 run
RefSeq:NM_078700.4 run
Other Identifiers
151863_at
1634413_at
33059
GO:0000978
GO:0000981
GO:0001709
GO:0003006
GO:0003677
GO:0003700
GO:0005515
GO:0005524
GO:0005634
GO:0006355
GO:0006357
GO:0007366
GO:0007367
GO:0007377
GO:0007400
GO:0007411
GO:0007419
GO:0007540
GO:0043565
GO:0045892
GO:0045893
GO:0045944
GO:0048592
GO:0048856
Participates
as an input of
SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)
RUNX3 binds TP53 (Drosophila melanogaster)
RUNX3 binds ZFHX3 (Drosophila melanogaster)
RUNX3 binds SMAD3 and SMAD4 (Drosophila melanogaster)
CBFB binds RUNX3 (Drosophila melanogaster)
RUNX3 binds TEADs and YAP1 (Drosophila melanogaster)
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Drosophila melanogaster)
as a component of
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Drosophila melanogaster)
RUNX3:TP53 tetramer [nucleoplasm] (Drosophila melanogaster)
RUNX3:ZFHX3 [nucleoplasm] (Drosophila melanogaster)
RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] (Drosophila melanogaster)
RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm] (Drosophila melanogaster)
RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Drosophila melanogaster)
RUNX3:CBFB [nucleoplasm] (Drosophila melanogaster)
as an output of
RUNX3 translocates to the nucleus (Drosophila melanogaster)
Other forms of this molecule
run [plasma membrane]
run [nucleoplasm]
run [nucleoplasm]
run [cytosol]
run [nucleoplasm]
phospho-run [nucleoplasm]
run [nucleoplasm]
run [cytosol]
run [nucleoplasm]
run [nucleoplasm]
run [cytosol]
run [cytosol]
phospho-run [nucleoplasm]
phospho-run [nucleoplasm]
phospho-run [nucleoplasm]
phospho-run [nucleoplasm]
run [nucleoplasm]
run [nucleoplasm]
run [cytosol]
run [cytosol]
phospho-run [nucleoplasm]
phospho-run [nucleoplasm]
run [nucleoplasm]
phospho-run [nucleoplasm]
phospho-run [nucleoplasm]
phospho-run [nucleoplasm]
Inferred From
RUNX3 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001285501.1
,
NP_523424.2
ENSEMBL
FBpp0311837
,
FBpp0076971
,
FBgn0003300
,
FBtr0077279
,
FBtr0345922
FlyBase
FBgn0003300
PRO
P22814
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24039 BRO
0.691
7
UniProt:Q24040
1
Bgb [nucleoplasm]
(R-DME-8865293)
0.502
2
UniProt:P16371 gro
9
GRO [nucleoplasm]
(R-DME-205750)
gro [nucleoplasm]
(R-DME-3322374)
gro [nucleoplasm]
(R-DME-3322370)
gro [nucleoplasm]
(R-DME-3322369)
gro [nucleoplasm]
(R-DME-3322378)
gro [nucleoplasm]
(R-DME-212327)
gro [nucleoplasm]
(R-DME-212377)
gro [nucleoplasm]
(R-DME-3322363)
gro [nucleoplasm]
(R-DME-212354)
0.502
2
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text