Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
LOC107050724 [cytosol]
Stable Identifier
R-GGA-195066
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
VAV1, A0A8V0XJF3
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
VAV1 is a GEF for Rho/Rac family GTPases (Gallus gallus)
PIP3:VAV1,2,3 [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
VAV family:PIP2 [plasma membrane] (Gallus gallus)
VAV family [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
p-SLP-76 binds VAV (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
p-SLP-76:VAV [cytosol] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-stimulation by CD28 (Gallus gallus)
CD28 dependent Vav1 pathway (Gallus gallus)
Activation of Vav1 (Gallus gallus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Translocation of Vav1 to CD28 (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
BTK binds BTK inhibitors (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
BTK:BTK inhibitors [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
IL3 stimulation induces Vav binding to Tec kinase (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
TEC:VAV1 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Regulation of signaling by CBL (Gallus gallus)
CBL binds VAV (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Autophosphorylation of BTK/ITK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Phosphorylation of TEC kinases by p-SYK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
FCERI mediated MAPK activation (Gallus gallus)
Phosphorylation and activation of VAV (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Recruitment of VAV to p-SLP-76 (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
Phosphorylation of VAV (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
p75 NTR receptor-mediated signalling (Gallus gallus)
Cell death signalling via NRAGE, NRIF and NADE (Gallus gallus)
NRAGE signals death through JNK (Gallus gallus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Gallus gallus)
GEFs [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (12/13) signalling events (Gallus gallus)
GEFs activate RhoA,B,C (Gallus gallus)
GEFs [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Phosphorylation and activation of VAV1 (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
Src kinases phosphorylate VAV (Gallus gallus)
PIP3:VAV1,2,3 [plasma membrane] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
VAV family [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase cycle (Gallus gallus)
RAC1 GTPase cycle (Gallus gallus)
RAC1 GEFs activate RAC1 (Gallus gallus)
RAC1 GEFs [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
RAC2 GTPase cycle (Gallus gallus)
RAC2 GEFs activate RAC2 (Gallus gallus)
RAC2 GEFs [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
RHOA GTPase cycle (Gallus gallus)
RHOA GEFs activate RHOA (Gallus gallus)
RHOA GEFs [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
RHOG GTPase cycle (Gallus gallus)
RHOG GEFs activate RHOG (Gallus gallus)
RHOG GEFs [cytosol] (Gallus gallus)
LOC107050724 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0XJF3
Gene Names
LOC107050724
Reference Genes
ENSEMBL:ENSGALG00010003064.1
UCSC:A0A8V0XJF3 LOC107050724
Other Identifiers
107050724
GO:0001784
GO:0002376
GO:0005085
GO:0005515
GO:0005737
GO:0007165
GO:0008270
GO:0030101
GO:0031295
GO:0035556
GO:0042267
Participates
as a member of
RHOA GEFs [cytosol] (Gallus gallus)
RAC2 GEFs [cytosol] (Gallus gallus)
RAC1 GEFs [cytosol] (Gallus gallus)
RHOG GEFs [cytosol] (Gallus gallus)
GEFs [cytosol] (Gallus gallus)
VAV family [cytosol] (Gallus gallus)
VAV1,2,3 [cytosol] (Gallus gallus)
as an input of
IL3 stimulation induces Vav binding to Tec kinase (Gallus gallus)
CBL binds VAV (Gallus gallus)
Phosphorylation and activation of VAV1 (Gallus gallus)
Translocation of Vav1 to CD28 (Gallus gallus)
as a component of
TEC:VAV1 [cytosol] (Gallus gallus)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Gallus gallus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Gallus gallus)
Other forms of this molecule
phospho-LOC107050724 [plasma membrane]
phospho-LOC107050724 [cytosol]
LOC107050724 [plasma membrane]
Inferred From
VAV1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSGALP00010004390
,
ENSGALG00010003064
,
ENSGALT00010007334
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text