2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+

Stable Identifier
R-GGA-373042
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial matrix
ReviewStatus
5/5
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2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+
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Mitochondrial 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase complex catalyzes the reaction of 2-oxoglutarate, CoASH, and NAD+ to form succinylCoA, CO2, and NADH + H+. No chicken enzyme complex capable of catalyzing this reaction has been identified, although open reading frames capable of encoding proteins closely similar to each of the three authentic human 2-oxoglutarate dehydrogenase E1, E2, and E3 subunits have been identified computationally in the ENSEMBL chicken gene set. This reaction is inferred from its human counterpart.
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Catalyst Activity

dihydrolipoyl dehydrogenase (NADH) activity of 2-oxoglutarate dehydrogenase complex [mitochondrial matrix]

Physical Entity
2-oxoglutarate dehydrogenase complex [mitochondrial matrix] (Gallus gallus)
Activity
dihydrolipoyl dehydrogenase (NADH) activity (GO:0004148)
Inferred From
OGDH dimer decarboxylates 2-OG (Homo sapiens)
Authored
D'Eustachio, P  (2008-09-10)
Created
D'Eustachio, P  (2008-07-12)
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