SHC1 events in ERBB2 signaling

Stable Identifier
R-HSA-1250196
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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SHC1 events in ERBB2 signaling
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All ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphorylated C-tail tyrosine residues in either EGFR (Y1148 and Y1173), ERBB2 (Y1196, Y1221, Y1222 and Y1248), ERBB3 (Y1328) or ERBB4 (Y1188 and Y1242 in JM-A CYT1 isoform, Y1178 and Y1232 in JM-B CYT1 isoform, Y1172 and Y1226 in JM-A CYT2 isoform). SHC1 recruitment is followed by phosphorylation (Segatto et al. 1993, Soler et al. 1994), and the phosphorylated SHC1 recruits GRB2:SOS1 complex (Xie et al. 1995), which leads to SOS1-mediated guanyl-nucleotide exchange on RAS (Xie et al. 1995) and downstream activation of RAF and MAP kinases.
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Events
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as an event of
Orthologous Events
SHC1 events in ERBB2 signaling (Bos taurus)
SHC1 events in ERBB2 signaling (Caenorhabditis elegans)
SHC1 events in ERBB2 signaling (Canis familiaris)
SHC1 events in ERBB2 signaling (Danio rerio)
SHC1 events in ERBB2 signaling (Drosophila melanogaster)
SHC1 events in ERBB2 signaling (Gallus gallus)
SHC1 events in ERBB2 signaling (Mus musculus)
SHC1 events in ERBB2 signaling (Rattus norvegicus)
SHC1 events in ERBB2 signaling (Sus scrofa)
SHC1 events in ERBB2 signaling (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-04-15)
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