Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PLAU(21-177) [plasma membrane]
Stable Identifier
R-HSA-158956
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
urokinase plasminogen activator chain A
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Dissolution of Fibrin Clot (Homo sapiens)
plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177) [plasma membrane] (Homo sapiens)
urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177) [plasma membrane] (Homo sapiens)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177) [plasma membrane] (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431):SERPINE1 [plasma membrane] (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177) [plasma membrane] (Homo sapiens)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177) [plasma membrane] (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431):SERPINE1:SERPINB2 [plasma membrane] (Homo sapiens)
PI-PLAUR:PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
PLAU(21-177) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00749 PLAU
Gene Names
PLAU
Chain
signal peptide:1-20, chain:21-431, chain:21-177, chain:156-177, chain:179-431
Reference Genes
BioGPS Gene:5328 PLAU
COSMIC (genes):PLAU PLAU
CTD Gene:5328 PLAU
dbSNP Gene:5328 PLAU
ENSEMBL:ENSG00000122861 PLAU
ENSEMBL_homo_sapiens_GENE:ENSG00000122861.16 PLAU
HGNC:9052 PLAU
KEGG Gene (Homo sapiens):5328 PLAU
Monarch:5328 PLAU
NCBI Gene:5328 PLAU
OMIM:191840 PLAU
UCSC:P00749 PLAU
Reference Transcript
RefSeq:XM_011539866.2 PLAU
RefSeq:NM_001145031.2 PLAU
RefSeq:NM_001319191.1 PLAU
RefSeq:NM_002658.4 PLAU
Other Identifiers
11717154_a_at
11717886_a_at
11754119_a_at
16706180
205479_PM_s_at
205479_s_at
211668_PM_s_at
211668_s_at
3252040
3252042
3252043
3252044
3252045
3252047
3252049
3252050
3252051
3252052
3252053
3252054
3252056
3252058
3252061
3252062
3252063
3252064
37310_at
5328
7928429
A_23_P24104
A_33_P3306146
GE59641
GO:0001666
GO:0003824
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005925
GO:0006508
GO:0006935
GO:0007155
GO:0007165
GO:0007596
GO:0007599
GO:0008233
GO:0008236
GO:0009897
GO:0009986
GO:0010469
GO:0010755
GO:0010757
GO:0014909
GO:0014910
GO:0016787
GO:0023052
GO:0030155
GO:0030335
GO:0031410
GO:0031639
GO:0033628
GO:0035579
GO:0038195
GO:0042060
GO:0042127
GO:0042730
GO:0043226
GO:0048870
GO:0051604
GO:0051917
GO:0051918
GO:0061041
GO:0070062
GO:0070821
GO:0097180
GO:0098637
GO:0140096
GO:1905370
GO:2000097
HMNXSV003015345
ILMN_1656057
PH_hs_0031336
TC10000475.hg
X02419_rna1_s_at
g340155_3p_s_at
g4505862_3p_a_at
Participates
as a component of
PLAU(21-177):PLAU(179-431) [plasma membrane] (Homo sapiens)
Other forms of this molecule
PLAU(179-431) [plasma membrane]
PLAU(21-431) [extracellular region]
PLAU(21-431) [specific granule membrane]
PLAU(21-431) [plasma membrane]
PLAU(21-431) [tertiary granule membrane]
Inferred To
Plau [plasma membrane]
(Mus musculus)
Plau [plasma membrane]
(Rattus norvegicus)
PLAU [plasma membrane]
(Bos taurus)
PLAU [plasma membrane]
(Canis familiaris)
PLAU [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_011538168.1
,
NP_001306120.1
,
NP_002649.1
,
NP_001138503.1
ZINC - World Drugs
UROK_HUMAN
Guide to Pharmacology - Targets
2393
OpenTargets
ENSG00000122861
ZINC - FDA approved
UROK_HUMAN
ZINC - Substances
UROK_HUMAN
ZINC target
P00749
PRO
P00749
PDB
3MHW
,
4XSK
,
2VIN
,
1OWD
,
5ZC5
,
7ZRT
,
6JYP
,
4FU7
,
5ZA8
,
4OS1
,
2I9A
,
4MNW
,
6AG9
,
2VIW
,
1SQT
,
4FUH
,
1KDU
,
1C5Y
,
1W14
,
3BT1
,
4X1N
,
6NMB
,
1GJ7
,
1FV9
,
1SQA
,
5ZAE
,
1F5L
,
1W0Z
,
5YC7
,
6JYQ
,
4FUF
,
5Z1C
,
1OWK
,
3OY6
,
4K24
,
1EJN
,
1F92
,
6XVD
,
5ZAJ
,
4OS5
,
4OS7
,
5ZA7
,
1OWJ
,
1URK
,
1O5A
,
6L04
,
7ZRR
,
4ZKN
,
4X1P
,
3MWI
,
1GI8
,
2O8W
,
4X0W
,
2NWN
,
4ZKS
,
1VJA
,
4DW2
,
1OWH
,
1C5X
,
2VIQ
,
4FU9
,
1W11
,
3KGP
,
3M61
,
6AG7
,
1LMW
,
4JK5
,
4X1R
,
4ZHM
,
6AG2
,
5ZAH
,
1O5C
,
6AG3
,
2O8T
,
1GJD
,
5YC6
,
4OS2
,
1SQO
,
5ZAG
,
4MNV
,
4X1Q
,
4DVA
,
1O3P
,
1GJ9
,
1GI9
,
4H42
,
2FD6
,
5WXR
,
2VIO
,
1C5Z
,
4OS6
,
5HGG
,
1VJ9
,
1W13
,
1SC8
,
4FU8
,
1GJB
,
5ZAF
,
7VM7
,
7VM6
,
4FUE
,
4FUI
,
3OY5
,
5WXT
,
7VM5
,
4OS4
,
3KID
,
3BT2
,
3QN7
,
4FUJ
,
2VNT
,
4MNY
,
3U73
,
1OWE
,
3IG6
,
1O5B
,
1W12
,
3OX7
,
4ZHL
,
4FUC
,
4FUG
,
2VIV
,
5WXQ
,
5XG4
,
1GJC
,
2O8U
,
4GLY
,
1GJ8
,
5WXO
,
4FUD
,
1OWI
,
3KHV
,
5WXP
,
4ZKO
,
1U6Q
,
1W10
,
4X1S
,
2I9B
,
2VIP
,
4MNX
,
1GI7
,
2R2W
,
7DZD
,
1GJA
,
4ZKR
,
7VM4
,
5ZA9
,
4FUB
,
6L05
,
3PB1
,
1F5K
,
4JK6
,
1C5W
,
5WXF
,
5WXS
ZINC - Investigational
UROK_HUMAN
HPA
ENSG00000122861-PLAU
GeneCards
P00749
Ensembl
ENSP00000361850
,
ENSG00000122861
,
ENSP00000388474
,
ENST00000372764
,
ENST00000446342
Pharos - Targets
P00749
Orphanet
18967
ZINC - Predictions - Purchasable
UROK_HUMAN
HMDB Protein
HMDBP02055
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55000 SLUR1
0.59
2
UniProt:P05121 SERPINE1
3
SERPINE1 [plasma membrane]
(R-HSA-158922)
SERPINE1 [platelet alpha granule lumen]
(R-HSA-114649)
SERPINE1 [extracellular region]
(R-HSA-158797)
0.59
2
UniProt:Q03405 PLAUR
7
PLAUR [endoplasmic reticulum membrane]
(R-HSA-162703)
GPI-PLAUR [endoplasmic reticulum membrane]
(R-HSA-162687)
PLAUR(306-335) [endoplasmic reticulum lumen]
(R-HSA-162707)
PLAUR(23-335) [endoplasmic reticulum membrane]
(R-HSA-162866)
GPI-PLAUR [plasma membrane]
(R-HSA-158946)
PLAUR [plasma membrane]
(R-HSA-6806165)
GPI-PLAUR [specific granule membrane]
(R-HSA-6806143)
0.564
3
UniProt:Q03405-1 PLAUR
0.558
2
UniProt:Q9UKQ2 ADA28
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text