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RAP1A [cytosol]
Stable Identifier
R-HSA-169884
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rap-1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
ARMS-mediated activation (Homo sapiens)
BRAF in Rap1-GTP complex:BRAF complex autophosphorylates (Homo sapiens)
Rap1-GTP complex:BRAF complex [plasma membrane] (Homo sapiens)
Rap1-GTP [cytosol] (Homo sapiens)
RAP1A [cytosol] (Homo sapiens)
Rap1-GTP complex:p-S,T-BRAF complex [plasma membrane] (Homo sapiens)
Rap1-GTP [cytosol] (Homo sapiens)
RAP1A [cytosol] (Homo sapiens)
C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)
Rap1-GDP [cytosol] (Homo sapiens)
RAP1A [cytosol] (Homo sapiens)
Rap1-GTP [cytosol] (Homo sapiens)
RAP1A [cytosol] (Homo sapiens)
Rap1-GTP complex binds BRAF complex (Homo sapiens)
Rap1-GTP complex [plasma membrane] (Homo sapiens)
Rap1-GTP [cytosol] (Homo sapiens)
RAP1A [cytosol] (Homo sapiens)
Rap1-GTP complex:BRAF complex [plasma membrane] (Homo sapiens)
Rap1-GTP [cytosol] (Homo sapiens)
RAP1A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62834 RAP1A
Gene Names
RAP1A, KREV1
Chain
chain:1-181, propeptide:182-184
Reference Genes
BioGPS Gene:5906 RAP1A
COSMIC (genes):RAP1A RAP1A
CTD Gene:5906 RAP1A
dbSNP Gene:5906 RAP1A
ENSEMBL:ENSG00000116473 RAP1A
HGNC:9855 RAP1A
KEGG:hsa:5906 RAP1A
Monarch:5906 RAP1A
NCBI Gene:5906 RAP1A
OMIM:179520 RAP1A
UCSC:P62834 RAP1A
Reference Transcript
RefSeq:NM_001291896.1 RAP1A
RefSeq:XM_017001962.1 RAP1A
RefSeq:NM_001010935.2 RAP1A
RefSeq:XM_017001963.1 RAP1A
RefSeq:XM_017001964.1 RAP1A
RefSeq:NM_002884.3 RAP1A
Other Identifiers
11716097_a_at
11716098_a_at
11716099_s_at
16668712
1848_at
202362_PM_at
202362_at
228548_PM_at
228548_at
2351873
2351879
2351882
2351904
2351905
2351906
2351907
2351910
2351911
2351912
2351915
2351916
2351918
2351919
2351920
2351921
2351922
2351923
2351924
2351925
3544134
3544136
38756_at
45178_at
5906
70281_at
7903988
A_14_P128424
A_23_P51754
A_33_P3342285
GE61649
GE79260
GE86022
GO:0000166
GO:0003824
GO:0003924
GO:0003925
GO:0005085
GO:0005515
GO:0005525
GO:0005737
GO:0005768
GO:0005769
GO:0005770
GO:0005829
GO:0005886
GO:0007165
GO:0007264
GO:0007399
GO:0010008
GO:0010976
GO:0016020
GO:0016079
GO:0016192
GO:0016787
GO:0019003
GO:0030054
GO:0031267
GO:0031410
GO:0032045
GO:0032486
GO:0035579
GO:0038180
GO:0043005
GO:0043226
GO:0043547
GO:0044877
GO:0045860
GO:0048471
GO:0048856
GO:0061028
GO:0070062
GO:0070161
GO:0070374
GO:0071320
GO:0072659
GO:0097225
GO:0098696
GO:0098772
GO:0098793
GO:0098978
GO:1901888
GO:1990090
GO:2000301
GO:2001214
HMNXSV003010206
Hs.306647.0.S1_3p_at
ILMN_1766176
ILMN_1809191
M22995_at
PH_hs_0027523
PH_hs_0036604
TC01000979.hg
TC01004621.hg
g4506412_3p_at
p25691
Participates
as a component of
Rap1-GTP [cytosol] (Homo sapiens)
Rap1-GDP [cytosol] (Homo sapiens)
Other forms of this molecule
RAP1A [plasma membrane]
RAP1A [endosome membrane]
RAP1A [specific granule membrane]
Inferred To
rap1aa [cytosol]
(Danio rerio)
RAP1A [cytosol]
(Bos taurus)
RAP1A [cytosol]
(Caenorhabditis elegans)
RAP1A [cytosol]
(Canis familiaris)
RAP1A [cytosol]
(Dictyostelium discoideum)
RAP1A [cytosol]
(Drosophila melanogaster)
RAP1A [cytosol]
(Gallus gallus)
RAP1A [cytosol]
(Mus musculus)
RAP1A [cytosol]
(Rattus norvegicus)
RAP1A [cytosol]
(Saccharomyces cerevisiae)
RAP1A [cytosol]
(Sus scrofa)
rap1a [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001010935.1
,
XP_016857452.1
,
XP_016857453.1
,
NP_001278825.1
,
XP_016857451.1
,
NP_002875.1
OpenTargets
ENSG00000116473
ENSEMBL
ENST00000369709
,
ENSP00000358723
,
ENSP00000509234
,
ENSP00000348786
,
ENST00000687939
,
ENST00000356415
HPA
ENSG00000116473-RAP1A
ZINC - Substances
RAP1A_HUMAN
ZINC target
P62834
PRO
P62834
Pharos - Targets
P62834
GlyGen
P62834
PDB
1GUA
,
4KVG
,
3KUC
,
1C1Y
HMDB Protein
HMDBP01963
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.623
2
UniProt:Q92845 KIFAP3
3
KIFAP3 [cytosol]
(R-HSA-984736)
KIFAP3 [cilium]
(R-HSA-5624882)
KIFAP3 [ciliary tip]
(R-HSA-5625382)
0.527
2
UniProt:Q8TAG9 EXOC6
2
EXOC6 [plasma membrane]
(R-HSA-265041)
EXOC6 [cytosol]
(R-HSA-5623384)
0.527
2
UniProt:P52306 RAP1GDS1
1
RAP1GDS1 [mitochondrial outer membrane]
(R-HSA-9693756)
0.527
3
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