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Go!
LDL [extracellular region]
Stable Identifier
R-HSA-171131
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
low-density lipoprotein complex
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Heme signaling (Homo sapiens)
FeHM oxidises LDL,HDL (Homo sapiens)
LDL,HDL [extracellular region] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
OLR1 binds to oxidized LDL (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
OLR1 bound to oxidized LDL [plasma membrane] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
FGR binds LDL:LRP8 (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
LDL:LRP8:FGR [plasma membrane] (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
FGR binds and phosphorylates LRP8 (Homo sapiens)
LDL:LRP8:FGR [plasma membrane] (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
LDL:p-LRP8:FGR [plasma membrane] (Homo sapiens)
LDL:p-LRP8 [plasma membrane] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
LDL binds to LRP8 (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
PECAM1 is phosphorylated (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
LDL + LDLR => LDL:LDLR complex (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
LSR trimer binds LDL (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
LSR trimer:LDL [plasma membrane] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
Plasma lipoprotein remodeling (Homo sapiens)
LDL remodeling (Homo sapiens)
CETP-mediated lipid exchange: LDL gains cholesterol ester (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
LDL:cholesterol ester [extracellular region] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
apolipoprotein(a) + LDL => Lp(a) (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
Lp(a) [extracellular region] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging by Class B Receptors (Homo sapiens)
SCARB1 (SR-BI, CLA-1) binds ligands (Homo sapiens)
Ligands of SCARB1 [extracellular region] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
SCARB1:Ligand [plasma membrane] (Homo sapiens)
Ligands of SCARB1 [extracellular region] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
SCARB1:ligand is endocytosed (Homo sapiens)
SCARB1:Endocytosed Ligand [plasma membrane] (Homo sapiens)
Endocytosed Ligands of SCARB1 [extracellular region] (Homo sapiens)
LDL [extracellular region] (Homo sapiens)
General
LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. LDL complexes contain single molecules of apoB-100, but their content of lipids is variable (Chapman et al. 1988; Mateu et al. 1972; Tardieu et al. 1976). High levels of LDL in the blood are strongly correlated with increased risk of atherosclerosis, and recent studies have raised the possibility that this risk is further increased in individuals whose blood LDL population is enriched in high-density (low lipid content) LDL complexes (Rizzo and Berneis 2006). The LDL complex annotated here contains an average lipid composition.
Participants
components
APOB(28-4563) [extracellular region]
(Homo sapiens)
x 1500
CHEST [extracellular region]
x 670
CHOL [extracellular region]
x 690
PL [extracellular region]
x 170
TAGs [extracellular region]
Participates
as a component of
LSR trimer:LDL [plasma membrane] (Homo sapiens)
Lp(a) [extracellular region] (Homo sapiens)
LDL:cholesterol ester [extracellular region] (Homo sapiens)
OLR1 bound to oxidized LDL [plasma membrane] (Homo sapiens)
LDL:p-LRP8 [plasma membrane] (Homo sapiens)
LDL:LRP8 [plasma membrane] (Homo sapiens)
as an input of
LSR trimer binds LDL (Homo sapiens)
LDL + LDLR => LDL:LDLR complex (Homo sapiens)
apolipoprotein(a) + LDL => Lp(a) (Homo sapiens)
CETP-mediated lipid exchange: LDL gains cholesterol ester (Homo sapiens)
OLR1 binds to oxidized LDL (Homo sapiens)
LDL binds to LRP8 (Homo sapiens)
as a member of
Endocytosed Ligands of SCARB1 [extracellular region] (Homo sapiens)
Ligands of SCARB1 [extracellular region] (Homo sapiens)
LDL,HDL [extracellular region] (Homo sapiens)
This entity regulates
Positively
PECAM1 is phosphorylated
(Homo sapiens)
Inferred To
LDL [extracellular region]
(Bos taurus)
LDL [extracellular region]
(Canis familiaris)
LDL [extracellular region]
(Gallus gallus)
LDL [extracellular region]
(Mus musculus)
LDL [extracellular region]
(Rattus norvegicus)
LDL [extracellular region]
(Sus scrofa)
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