PECAM1 is phosphorylated

Stable Identifier
R-HSA-435244
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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PECAM1 is phosphorylated
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LDL causes a transient increase in p38 MAPK activity in platelets. After an initial phase in which LDL leads to the activation of p38MAPK, LDL leads to tyrosine phosphorylation and thereby activation of PECAM-1, which in turn leads to binding and stimulation of the Ser/Thr phosphatases PP1/PP2A which reduce the activity of p38MAPK by dephosphorylation.
Literature References
PubMed ID Title Journal Year
12775720 Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits low density lipoprotein-induced signaling in platelets

Akkerman, JW, Gorter, G, Ferreira, IA, Relou, IA, van Rijn, HJ

J Biol Chem 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
LDL [extracellular region] (Homo sapiens)
Orthologous Events
PECAM1 is phosphorylated (Bos taurus)
PECAM1 is phosphorylated (Canis familiaris)
PECAM1 is phosphorylated (Gallus gallus)
PECAM1 is phosphorylated (Mus musculus)
PECAM1 is phosphorylated (Rattus norvegicus)
PECAM1 is phosphorylated (Sus scrofa)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-09-08)
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