Reactome | MAT2A [cytosol]

MAT2A [cytosol]

Stable Identifier

R-HSA-174363

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MAT II

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P31153 MAT2A

Gene Names

MAT2A, AMS2, MATA2

Chain

chain:1-395

Reference Genes

BioGPS Gene:4144 MAT2A

COSMIC (genes):MAT2A MAT2A

CTD Gene:4144 MAT2A

dbSNP Gene:4144 MAT2A

ENSEMBL:ENSG00000168906 MAT2A

ENSEMBL_homo_sapiens_GENE:ENSG00000168906.13 MAT2A

HGNC:6904 MAT2A

KEGG Gene (Homo sapiens):4144 MAT2A

Monarch:4144 MAT2A

NCBI Gene:4144 MAT2A

OMIM:601468 MAT2A

UCSC:P31153 MAT2A

Reference Transcript

RefSeq:NM_005911.5 MAT2A

Other Identifiers

11734751_x_at

11751134_x_at

11751457_a_at

11756985_a_at

11757376_s_at

11760938_a_at

16882258

17123316

200768_PM_s_at

200768_s_at

200769_PM_s_at

200769_s_at

2491623

2491624

2491625

2491626

2491627

2491629

2491630

2491632

2491634

2491636

2491638

2491640

2491641

2491642

2491643

2491644

2491645

2491646

2491647

2491648

2491649

2491650

2491651

2491652

2491654

2491656

2688877

2688878

2688879

2688880

2688881

32571_at

3426023

3426028

4144

80415_at

8043187

A_23_P401568

A_32_P87703

A_33_P3403044

A_33_P3403048

GE59950

GO:0000166

GO:0003824

GO:0004478

GO:0005515

GO:0005524

GO:0005829

GO:0006556

GO:0006730

GO:0006790

GO:0016740

GO:0034214

GO:0036094

GO:0042802

GO:0046872

GO:0048269

GO:0051291

GO:0065003

GO:1990830

HMNXSV003001312

HMNXSV003025543

ILMN_1737298

PH_hs_0027696

TC02000511.hg

X68836_at

g12804546_3p_at

g12804546_3p_s_at

g5174528_3p_a_at

Participates

as a component of

MAT2A:K+:2Mg2+ [cytosol] (Homo sapiens)

Inferred To

MAT2AA [cytosol] (Danio rerio)

MAT1A [cytosol] (Dictyostelium discoideum)

mat2a [cytosol] (Xenopus tropicalis)

MAT2L [cytosol] (Gallus gallus)

MAT2A [cytosol] (Bos taurus)

MAT2A [cytosol] (Canis familiaris)

MAT2A [cytosol] (Mus musculus)

MAT2A [cytosol] (Rattus norvegicus)

MAT2A [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005902.1

OpenTargets

ENSG00000168906

IntEnz

2.5.1.6

GeneCards

P31153

HPA

ENSG00000168906-MAT2A

Ensembl

ENST00000409017, ENSG00000168906, ENSP00000386353, ENST00000306434, ENSP00000303147

PRO

P31153

Pharos - Targets

P31153

Orphanet

25436

HMDB Protein

HMDBP00405

PDB

4NDN, 5A1G, 6G6R, 7BHU, 6FCD, 6P9V, 7KCF, 5A1I, 7BHV, 7RWH, 7KDB, 6FBO, 7KDA, 6FBN, 7BHW, 7RXV, 7L1A, 5UGH, 7BHX, 8P1T, 7RWG, 7RXW, 7LNH, 6FAJ, 6FBP, 8P1W, 7RXX, 8P1V, 8OOG, 6WKB, 5A19, 4KTT, 7RW7, 8P4H, 6FCB, 7KCE, 7BHS, 8AXZ, 2P02, 7BHR, 7KCC, 7RW5, 4KTV, 6FWB, 7BHT

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P02795 MT2A	1	MT2A [cytosol] (R-HSA-1031707)	0.556	3
UniProt:O43663 PRC1	1	PRC1 [cytosol] (R-HSA-264441)	0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3

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