Reactome | Norepinephrine Neurotransmitter Release Cycle

Norepinephrine Neurotransmitter Release Cycle

Stable Identifier

R-HSA-181430

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Norepinephrine Neurotransmitter Release Cycle

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Noradrenalin release cycle consists of reacidification of the empty clathrin sculpted monoamine transport vesicle, loading of dopamine into reacidified clathrin coated monamine transport vesicle, conversion of dopamine into Noradrenalin, docking and priming of the noradrenalin synaptic veiscle and then release of noradrenalin synaptic vesicle. In the peripheral nervous system in the peripheral nervous system noradrenalin is stored in large and small dense vesicles and is realesed from large vesicles.

Literature References

PubMed ID	Title	Journal	Year
12519779	Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis Barclay, JW, Craig, TJ, Fisher, RJ, Ciufo, LF, Evans, GJ, Morgan, A, Burgoyne, RD	J Biol Chem	2003
17478680	How synaptotagmin promotes membrane fusion Martens, S, Kozlov, MM, McMahon, HT	Science	2007
17891149	Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids Stein, A, Radhakrishnan, A, Riedel, D, Fasshauer, D, Jahn, R	Nat Struct Mol Biol	2007