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AP2A1 [cytosol]
Stable Identifier
R-HSA-182143
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Adaptor protein complex AP-2 alpha-1 subunit
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
Clathrin internalises EPH:EFN complexes (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
Nef Mediated CD4 Down-regulation (Homo sapiens)
Degradation of CD4 (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
CD4:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
CD4:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Nef Mediated CD8 Down-regulation (Homo sapiens)
Degradation of CD8 (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
CD8:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
CD8:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
AP2 binds chlorpromazine (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
AP2:chlorpromazine [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Homo sapiens)
FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)
clathrin:AP-2 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
WNT5A-dependent internalization of FZD4 (Homo sapiens)
WNT5A:FZD4 is endocytosed (Homo sapiens)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Homo sapiens)
clathrin:AP-2 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Homo sapiens)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Homo sapiens)
clathrin:AP-2 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
clathrin:AP-2 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
AP-2 directly binds some endocytic cargo (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
AP2:chlorpromazine [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
AP2 binds chlorpromazine (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
AP2:chlorpromazine [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
Recruitment of AP-2 complex and clathrin (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95782 AP2A1
Gene Names
AP2A1, ADTAA, CLAPA1
Chain
chain:1-977
Reference Genes
BioGPS Gene:160 AP2A1
COSMIC (genes):AP2A1 AP2A1
CTD Gene:160 AP2A1
dbSNP Gene:160 AP2A1
ENSEMBL:ENSG00000196961 AP2A1
ENSEMBL_homo_sapiens_GENE:ENSG00000196961.13 AP2A1
HGNC:561 AP2A1
KEGG Gene (Homo sapiens):160 AP2A1
Monarch:160 AP2A1
NCBI Gene:160 AP2A1
OMIM:601026 AP2A1
UCSC:O95782 AP2A1
Reference Transcript
RefSeq:NM_130787.2 AP2A1
RefSeq:NM_014203.2 AP2A1
Other Identifiers
11728299_x_at
11748811_a_at
11752077_a_at
11752078_x_at
160
16864304
223237_3p_x_at
223237_PM_x_at
223237_x_at
229617_3p_x_at
229617_PM_x_at
229617_x_at
234068_PM_s_at
234068_s_at
3838887
3838888
3838891
3838892
3838893
3838894
3838895
3838896
3838897
3838902
3838904
3838905
3838906
3838907
3838908
3838909
3838911
3838912
3838914
3838916
3838918
3838920
3838921
3838922
3838925
3838926
3838927
3838928
3838929
3838931
3838932
3838933
49206_at
8030470
A_14_P132495
A_14_P200554
A_23_P4885
GE54012
GO:0005515
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0005829
GO:0005886
GO:0005905
GO:0005975
GO:0006886
GO:0006895
GO:0006897
GO:0009898
GO:0010976
GO:0015031
GO:0016020
GO:0016192
GO:0016323
GO:0016324
GO:0019901
GO:0030117
GO:0030122
GO:0030130
GO:0030131
GO:0030136
GO:0030154
GO:0030666
GO:0030669
GO:0031410
GO:0032433
GO:0032991
GO:0035615
GO:0036020
GO:0043226
GO:0044877
GO:0045334
GO:0048260
GO:0048856
GO:0050750
GO:0060090
GO:0072583
GO:0098794
GO:0098884
GO:1900126
GO:1901135
HMNXSV003018745
Hs.296426.1.S1_3p_a_at
Hs.296426.1.S1_3p_s_at
ILMN_1673108
ILMN_1815306
ILMN_2359211
PH_hs_0015334
TC19000747.hg
g12053344_3p_s_at
Participates
as a member of
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
Other forms of this molecule
AP2A1 [endolysosome membrane]
AP2A1 [endocytic vesicle membrane]
AP2A1 [plasma membrane]
AP2A1 [clathrin-coated endocytic vesicle membrane]
Inferred To
APL3 [cytosol]
(Saccharomyces cerevisiae)
AP2A1 [cytosol]
(Bos taurus)
AP2A1 [cytosol]
(Caenorhabditis elegans)
AP2A1 [cytosol]
(Canis familiaris)
AP2A1 [cytosol]
(Plasmodium falciparum)
AP2A1 [cytosol]
(Rattus norvegicus)
AP2A1 [cytosol]
(Sus scrofa)
AP2A1 [cytosol]
(Xenopus tropicalis)
ap2a1-2 [cytosol]
(Dictyostelium discoideum)
apl3 [cytosol]
(Schizosaccharomyces pombe)
AP-2alpha [cytosol]
(Drosophila melanogaster)
Ap2a1 [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_055018.2
,
NP_570603.2
OpenTargets
ENSG00000196961
GeneCards
O95782
HPA
ENSG00000196961-AP2A1
Ensembl
ENSP00000346246
,
ENSG00000196961
,
ENST00000354293
,
ENST00000359032
,
ENSP00000351926
PRO
O95782
Pharos - Targets
O95782
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.725
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.671
6
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.527
2
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.527
4
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