Reactome | p-Y53-SPRY1 [cytosol]

p-Y53-SPRY1 [cytosol]

Stable Identifier

R-HSA-182933

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho-Sprouty 1

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by EGFR (Homo sapiens)
    - EGFR downregulation (Homo sapiens)
      - CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Homo sapiens)
        
        Ub-p-Y53/55-SPRY1/2 [cytosol] (Homo sapiens)
        
        p-Y53/55-SPRY1/2 [cytosol] (Homo sapiens)
        
        p-Y53-SPRY1 [cytosol] (Homo sapiens)
      - CBL ubiquitinates Sprouty (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Homo sapiens)
        
        Ub-p-Y53/55-SPRY1/2 [cytosol] (Homo sapiens)
        
        p-Y53/55-SPRY1/2 [cytosol] (Homo sapiens)
        
        p-Y53-SPRY1 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Homo sapiens)
        
        p-Y53/55-SPRY1/2 [cytosol] (Homo sapiens)
        
        p-Y53-SPRY1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43609 SPRY1

Gene Names

SPRY1

Chain

chain:1-319

Reference Genes

BioGPS Gene:10252 SPRY1

COSMIC (genes):SPRY1 SPRY1

CTD Gene:10252 SPRY1

dbSNP Gene:10252 SPRY1

ENSEMBL:ENSG00000164056 SPRY1

HGNC:11269 SPRY1

KEGG:hsa:10252 SPRY1

Monarch:10252 SPRY1

NCBI Gene:10252 SPRY1

OMIM:602465 SPRY1

UCSC:O43609 SPRY1

Reference Transcript

Other Identifiers

10252

11717651_a_at

11717652_s_at

11738073_s_at

16970435

212558_PM_at

212558_at

2742233

2742238

2742239

2742240

2742241

2742242

2742243

2742244

2742245

2742246

2742247

2742248

2742249

2742251

2742252

2742253

2742254

2742255

2742256

2742257

38767_at

77631_at

8097282

A_23_P144476

A_33_P3268910

GE54355

GO:0000132

GO:0001656

GO:0001657

GO:0001759

GO:0005515

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0007010

GO:0007275

GO:0008285

GO:0009966

GO:0010719

GO:0016020

GO:0030154

GO:0030512

GO:0040037

GO:0043226

GO:0046580

GO:0048513

GO:0048856

GO:0051387

GO:0060449

GO:0060940

GO:0070371

GO:0070373

GO:1902747

HMNXSV003028206

HMNXSV003056854

Hs.88044.0.S1_3p_at

ILMN_1651610

ILMN_1691860

ILMN_1769280

ILMN_2329914

PH_hs_0025551

TC04000632.hg

Participates

as a member of

p-Y53/55-SPRY1/2 [cytosol] (Homo sapiens)

Other forms of this molecule

SPRY1 [plasma membrane]

SPRY1 [cytosol]

Inferred To

phospho-Spry1 [cytosol] (Mus musculus)

phospho-Spry1 [cytosol] (Rattus norvegicus)

phospho-SPRY1 [cytosol] (Bos taurus)

phospho-SPRY1 [cytosol] (Canis familiaris)

phospho-SPRY1 [cytosol] (Gallus gallus)

phospho-SPRY1 [cytosol] (Sus scrofa)

phospho-spry1 [cytosol] (Danio rerio)

phospho-spry1 [cytosol] (Xenopus tropicalis)

phospho-sty [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O4'-phospho-L-tyrosine at 53

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

ENSEMBL

ENSP00000480540, ENST00000651917, ENST00000339241, ENSP00000498292, ENST00000610581, ENSP00000481675, ENSP00000343785, ENST00000622283, ENSP00000377871, ENST00000394339

OpenTargets

ENSG00000164056

HPA

ENSG00000164056-SPRY1

PRO

O43609

Pharos - Targets

O43609

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.718	8
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.666	5
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.556	3
UniProt:O43597 SPRY2	8	p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) SPRY2 [cytosol] (R-HSA-182949) SPRY2 [plasma membrane] (R-HSA-182924) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3