Reactome | POLR1C [nucleoplasm]

POLR1C [nucleoplasm]

Stable Identifier

R-HSA-63498

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HsRPAC1, DNA-directed RNA polymerases I and III subunit RPAC1, DNA-directed RNA polymerase I and III 40 kDa polypeptide , RPA40, RPA39

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15160 POLR1C

Gene Names

POLR1C, POLR1E

Chain

initiator methionine:1, chain:2-346

Reference Genes

BioGPS Gene:9533 POLR1C

COSMIC (genes):POLR1C POLR1C

CTD Gene:9533 POLR1C

dbSNP Gene:9533 POLR1C

ENSEMBL:ENSG00000171453.20 POLR1C

HGNC:20194 POLR1C

KEGG Gene (Homo sapiens):9533 POLR1C

Monarch:9533 POLR1C

NCBI Gene:9533 POLR1C

OMIM:610060 POLR1C

UCSC:O15160 POLR1C

Reference Transcript

Other Identifiers

0004760070

0005720102

11719195_a_at

11740797_x_at

17009032

207515_PM_s_at

207515_s_at

209317_PM_at

209317_at

2908053

2908054

2908055

2908056

2908059

2908061

2908062

2908064

2908065

2908067

2908069

2908070

2908072

2908073

2908074

2908076

2908099

36460_at

8119842

9533

A_14_P119687

A_33_P3339103

GO:0000428

GO:0001054

GO:0001056

GO:0001650

GO:0003677

GO:0003899

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005666

GO:0005730

GO:0005736

GO:0005737

GO:0005829

GO:0006351

GO:0006360

GO:0006383

GO:0016740

GO:0032991

GO:0043226

GO:0046983

GO:0140098

HMNXSV003040440

ILMN_1746686

ILMN_1767219

PH_hs_0000558

g2266928_3p_at

g4759045_3p_a_at

Participates

as a component of

as an input of

Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)

Other forms of this molecule

POLR1C [cytosol]

Inferred To

polr1c [nucleoplasm] (Dictyostelium discoideum)

polr1c [nucleoplasm] (Xenopus tropicalis)

Polr1c [nucleoplasm] (Mus musculus)

Polr1c [nucleoplasm] (Rattus norvegicus)

POLR1C [nucleoplasm] (Bos taurus)

POLR1C [nucleoplasm] (Canis familiaris)

POLR1C [nucleoplasm] (Danio rerio)

POLR1C [nucleoplasm] (Gallus gallus)

POLR1C [nucleoplasm] (Sus scrofa)

rpac-40 [nucleoplasm] (Caenorhabditis elegans)

rpc40 [nucleoplasm] (Schizosaccharomyces pombe)

Polr1C [nucleoplasm] (Drosophila melanogaster)

RPC40 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_976035.1, NP_001305805.1

OpenTargets

ENSG00000171453

HPA

ENSG00000171453-POLR1C

GeneCards

O15160

Ensembl

ENST00000607635, ENSP00000496044, ENST00000304004, ENSP00000307212, ENSG00000171453, ENST00000642195, ENSP00000496683

PRO

O15160

Pharos - Targets

O15160

Orphanet

19587

HMDB Protein

HMDBP11916

PDB

7VBB, 7DU2, 7AEA, 7A6H, 7OB9, 7D59, 7D58, 7VBC, 7VBA, 7FJJ, 7OBB, 7FJI, 7AE3, 7DN3, 7AST, 7OBA, 7AE1

Interactors (110)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15531 NME1	1	NME1 [cytosol] (R-HSA-60022)	0.87	11
UniProt:P0DPB6 RPAC2			0.849	16
UniProt:Q9UKT9 IKZF3			0.841	9
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.781	9
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.781	11
UniProt:Q9UFD9 RIM3A			0.718	6
UniProt:Q9Y3Q8 T22D4			0.718	6
UniProt:Q96CA5 BIRC7			0.718	6
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.718	6
UniProt:Q8NA61-2 CBY2			0.696	5
UniProt:Q13064 MKRN3			0.696	5
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.696	5
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.621	3
UniProt:Q9HAV7 GRPEL1	1	GRPEL1 [mitochondrial inner membrane] (R-HSA-1252062)	0.601	4
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.601	4
UniProt:Q9BSW2 CRACR2A	2	CRACR2A [extracellular region] (R-HSA-6806289) CRACR2A [specific granule lumen] (R-HSA-6799553)	0.556	3
UniProt:P19237 TNNI1	1	TNNI1 [cytosol] (R-HSA-390539)	0.556	3
UniProt:Q5VWN6-2 TASOR2			0.556	3
UniProt:Q8IYA8 IHO1			0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q8WZ19 KCTD13	1	KCTD13 [cytosol] (R-HSA-9696533)	0.556	3
UniProt:Q9H1A7 RPB1C			0.556	3
UniProt:Q9BWF2 TRAIP	1	TRAIP [cytosol] (R-HSA-8851652)	0.556	3
UniProt:Q9UHP6 RSP14			0.556	3
UniProt:Q9NU63-3 ZFP57			0.556	3
UniProt:Q96LM5 CD045			0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:Q9Y3D9 MRPS23	1	MRPS23 [mitochondrial inner membrane] (R-HSA-5368249)	0.556	3
UniProt:Q9H4Y5 GSTO2	1	GSTO2 [cytosol] (R-HSA-176066)	0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:Q9Y5P6 GMPPB	1	GMPPB [cytosol] (R-HSA-532525)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q5RL73 RBM48			0.556	3
UniProt:Q7Z353 HDX			0.556	3
UniProt:P59991 KRTAP12-2	1	KRTAP12-2 [cytosol] (R-HSA-6810271)	0.556	3
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.556	3
UniProt:Q5T686 AVPI1			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:O95561 CA105			0.556	3
IntAct:EBI-22432104 CCSB ORF ID			0.556	3
UniProt:Q8WWB5 PIHD2			0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:P17482 HXB9			0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:Q01546 KRT76	1	KRT76 [cytosol] (R-HSA-6809633)	0.556	5
UniProt:O96000 NDUFB10	1	NDUFB10 [mitochondrial inner membrane] (R-HSA-60194)	0.556	3
UniProt:Q9NZ72 STMN3			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:Q5T3J3 LRIF1			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:B2RXF5 ZBT42			0.556	3
UniProt:Q9GZT8 NIF3L			0.556	3
UniProt:Q9Y2P0 ZN835			0.556	3
UniProt:Q8WXE1 ATRIP	1	ATRIP [nucleoplasm] (R-HSA-176231)	0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:P07954 FH	1	FH [mitochondrial matrix] (R-HSA-70980)	0.556	3
UniProt:Q8IXW7 Q8IXW7			0.556	3
UniProt:P46934-3 NEDD4			0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q0VAL7 Q0VAL7			0.556	3
UniProt:Q6PF18 MORN3			0.556	3
UniProt:Q8WUT1 Q8WUT1			0.556	3
UniProt:P0C7X2 ZNF688	1	ZNF688 [nucleoplasm] (R-HSA-2248884)	0.556	3
UniProt:Q6PI77 BHLH9			0.556	3
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.556	3
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:A8MW99 MEI4			0.556	3
UniProt:Q9BTD3 TM121			0.556	3
UniProt:Q9NZV7 ZIM2	1	ZIM2 [nucleoplasm] (R-HSA-974996)	0.556	5
UniProt:Q8IVP9 ZNF547	1	ZNF547 [nucleoplasm] (R-HSA-1973874)	0.556	3
UniProt:Q6PJQ5 FOXR2			0.556	3
UniProt:Q86TJ5 ZNF554	1	ZNF554 [nucleoplasm] (R-HSA-1973883)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.556	5
UniProt:Q9H0A9-2 SPATC1L			0.556	3
UniProt:Q9UFW8 CGBP1			0.556	3
UniProt:P35452-2 P354522			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:O75909-2 CCNK			0.556	3
UniProt:Q9H9P5-5 UNKL			0.556	3
UniProt:Q9NQY0 BIN3			0.556	3
UniProt:Q969Q6 P2R3C			0.556	5
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:Q14142 TRIM14	1	TRIM14 [cytosol] (R-HSA-5624345)	0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	5
UniProt:O43609 SPRY1	3	SPRY1 [plasma membrane] (R-HSA-182944) SPRY1 [cytosol] (R-HSA-182908) p-Y53-SPRY1 [cytosol] (R-HSA-182933)	0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q6ZNM6 TEX43			0.556	3
UniProt:A0A0A0MR80 A0A0A0MR80			0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.527	2
UniProt:Q8N448 LNX2			0.488	2