Reactome | CYP51A1 [endoplasmic reticulum membrane]

CYP51A1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-194721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

lanosterol 14alpha-demethylase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16850 CYP51A1

Gene Names

CYP51A1, CYP51

Chain

chain:1-509

Reference Genes

BioGPS Gene:1595 CYP51A1

COSMIC (genes):CYP51A1 CYP51A1

CTD Gene:1595 CYP51A1

dbSNP Gene:1595 CYP51A1

ENSEMBL:ENSG00000001630 CYP51A1

HGNC:2649 CYP51A1

KEGG:hsa:1595 CYP51A1

Monarch:1595 CYP51A1

NCBI Gene:1595 CYP51A1

OMIM:601637 CYP51A1

UCSC:Q16850 CYP51A1

Reference Transcript

Other Identifiers

11722563_x_at

11722564_at

1595

17059628

202314_PM_at

202314_at

216607_PM_s_at

216607_s_at

2684442

2684445

2684446

2684447

2684448

2684449

2684450

2684453

3060993

3060995

3060998

3060999

3061000

3061001

3061002

3061003

3061004

3061005

3061006

3061007

3061008

3061009

3061010

3061011

3061016

3061017

3061018

3061019

3061020

3061021

33389_at

3507516

3507518

3507519

3507520

3507522

3507524

3507526

8140864

8180268

A_23_P257716

GE523206

GE61171

GO:0003824

GO:0004497

GO:0005506

GO:0005783

GO:0005789

GO:0006629

GO:0006694

GO:0006695

GO:0008202

GO:0008398

GO:0016020

GO:0016125

GO:0016491

GO:0016705

GO:0016712

GO:0020037

GO:0042177

GO:0043226

GO:0043231

GO:0044283

GO:0046872

GO:0050709

GO:1900222

GO:1901617

HMNXSV003043512

Hs.226213.1.A1_3p_a_at

ILMN_1664718

PH_hs_0033255

TC07003059.hg

TC07003361.hg

U23942_at

g4503242_3p_at

Participates

as an output of

Inferred To

CYP51A1 [endoplasmic reticulum membrane] (Bos taurus)

CYP51A1 [endoplasmic reticulum membrane] (Canis familiaris)

CYP51A1 [endoplasmic reticulum membrane] (Danio rerio)

CYP51A1 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

CYP51A1 [endoplasmic reticulum membrane] (Gallus gallus)

CYP51A1 [endoplasmic reticulum membrane] (Mus musculus)

CYP51A1 [endoplasmic reticulum membrane] (Rattus norvegicus)

CYP51A1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

CYP51A1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

CYP51A1 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_000777.1, NP_001139624.1

ZINC - World Drugs

CP51A_HUMAN

Guide to Pharmacology - Targets

1374

ENSEMBL

ENST00000450723, ENSP00000406757, ENSP00000003100, ENST00000003100

OpenTargets

ENSG00000001630

ZINC - FDA approved

CP51A_HUMAN

ZINC - Substances

CP51A_HUMAN

ZINC target

Q16850

PRO

Q16850

PDB

4UHI, 8SS0, 6Q2T, 4UHL, 6UEZ, 3LD6, 3JUS, 3JUV, 8SBI

HPA

ENSG00000001630-CYP51A1

Pharos - Targets

Q16850

Orphanet

CYP51A1

ZINC - Predictions - Purchasable

CP51A_HUMAN

HMDB Protein

HMDBP00265

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0CG38 POTEI			0.527	2
UniProt:O43291 SPINT2	1	SPINT2 [extracellular region] (R-HSA-6800233)	0.527	3
UniProt:Q96FV3 TSN17			0.527	3
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.483	2

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