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MDH1 [cytosol]
Stable Identifier
R-HSA-198471
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
malate dehydrogenase 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Malate-aspartate shuttle (Homo sapiens)
MDH1 reduces OA (Homo sapiens)
MDH1 [cytosol] (Homo sapiens)
MDH1 dimer [cytosol] (Homo sapiens)
MDH1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40925 MDH1
Gene Names
MDH1, MDHA
Chain
initiator methionine:, chain:2-334
Reference Genes
BioGPS Gene:4190 MDH1
COSMIC (genes):MDH1 MDH1
CTD Gene:4190 MDH1
dbSNP Gene:4190 MDH1
ENSEMBL:ENSG00000014641 MDH1
ENSEMBL_homo_sapiens_GENE:ENSG00000014641.21 MDH1
HGNC:6970 MDH1
KEGG Gene (Homo sapiens):4190 MDH1
Monarch:4190 MDH1
NCBI Gene:4190 MDH1
OMIM:154200 MDH1
UCSC:P40925 MDH1
Reference Transcript
RefSeq:NM_001316374.1 MDH1
RefSeq:NM_001199111.1 MDH1
RefSeq:NM_005917.3 MDH1
RefSeq:NM_001199112.1 MDH1
Other Identifiers
11715372_a_at
11749961_a_at
16880596
200978_PM_at
200978_at
2485183
2485184
2485185
2485186
2485187
2485188
2485198
2485200
2485202
2485205
2485208
2485209
2485211
2485213
2485214
2485215
36608_at
4190
8042259
A_23_P101950
A_33_P3261818
D55654_at
GE57262
GO:0003824
GO:0004470
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005975
GO:0006091
GO:0006094
GO:0006099
GO:0006107
GO:0006108
GO:0006734
GO:0006739
GO:0016491
GO:0016615
GO:0016616
GO:0019752
GO:0030060
GO:0043226
GO:0047860
GO:0047995
GO:0055086
GO:0070062
HMNXSV003022073
ILMN_1656913
PH_hs_0004324
PH_hs_0035455
g5174538_3p_at
Participates
as a component of
MDH1 dimer [cytosol] (Homo sapiens)
Inferred To
MDH1 [cytosol]
(Bos taurus)
MDH1 [cytosol]
(Caenorhabditis elegans)
MDH1 [cytosol]
(Canis familiaris)
MDH1 [cytosol]
(Danio rerio)
MDH1 [cytosol]
(Dictyostelium discoideum)
MDH1 [cytosol]
(Drosophila melanogaster)
MDH1 [cytosol]
(Gallus gallus)
MDH1 [cytosol]
(Mus musculus)
MDH1 [cytosol]
(Rattus norvegicus)
MDH1 [cytosol]
(Sus scrofa)
MDH1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001186040.1
,
NP_001303303.1
,
NP_005908.1
,
NP_001186041.1
OpenTargets
ENSG00000014641
ZINC - Substances
MDHC_HUMAN
GeneCards
P40925
HPA
ENSG00000014641-MDH1
ZINC target
P40925
Ensembl
ENSP00000410073
,
ENSG00000014641
,
ENST00000233114
,
ENST00000544381
,
ENST00000432309
,
ENSP00000446395
,
ENSP00000233114
PRO
P40925
Pharos - Targets
P40925
ZINC - Predictions - Purchasable
MDHC_HUMAN
HMDB Protein
HMDBP00860
PDB
7RRL
,
7RM9
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48163 ME1
2
p-S336-ME1 [cytosol]
(R-HSA-9861606)
ME1 [cytosol]
(R-HSA-400119)
0.62
11
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
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