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p-S408-MEF2A [nucleoplasm]
Stable Identifier
R-HSA-199909
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho-Myocyte-specific enhancer factor 2A, MEFA_HUMAN, MEF2A
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S408-MEF2A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02078 MEF2A
Gene Names
MEF2A, MEF2
Chain
chain:1-507
Reference Genes
COSMIC (genes):MEF2A MEF2A
dbSNP Gene:4205 MEF2A
ENSEMBL:ENSG00000068305 MEF2A
Participates
as a member of
p-MEF2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T312,T319-MEF2A [nucleoplasm]
MEF2A [nucleoplasm]
Modified Residues
Name
O-phospho-L-serine at 408
Coordinate
408
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q06413 MEF2C
3
MEF2C [nucleoplasm]
(R-HSA-199938)
p-S396-MEF2C [nucleoplasm]
(R-HSA-199942)
p-T293,T300,S387-MEF2C [nucleoplasm]
(R-HSA-448838)
0.527
3
UniProt:Q14814 MEF2D
1
MEF2D [nucleoplasm]
(R-HSA-445328)
0.527
3
UniProt:P56524 HDAC4
3
polySUMO2,3-K559-HDAC4 [nucleoplasm]
(R-HSA-4616029)
monoSUMO1-K559-HDAC4 [nucleoplasm]
(R-HSA-4616016)
HDAC4 [nucleoplasm]
(R-HSA-351581)
0.489
2
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.462
4
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