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p-Y151-WASF3 [cytosol]
Stable Identifier
R-HSA-2029006
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y151-WAVE3
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
p-Y-WAVE [cytosol] (Homo sapiens)
p-Y151-WASF3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UPY6 WASF3
Gene Names
WASF3, KIAA0900, SCAR3, WAVE3
Chain
chain:1-502
Reference Genes
COSMIC (genes):WASF3 WASF3
dbSNP Gene:10810 WASF3
ENSEMBL:ENSG00000132970 WASF3
Participates
as a candidate of
p-Y-WAVE [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y151,S,T-WASF3 [cytosol]
WASF3 [cytosol]
Inferred To
phospho-SCAR [cytosol]
(Drosophila melanogaster)
phospho-wasf3 [cytosol]
(Xenopus tropicalis)
Homologues of p-Y151-WASF3 [cytosol]
(Drosophila melanogaster)
phospho-gukh [cytosol]
(Drosophila melanogaster)
phospho-wve-1 [cytosol]
(Caenorhabditis elegans)
phospho-Wasf3 [cytosol]
(Mus musculus)
phospho-Wasf3 [cytosol]
(Rattus norvegicus)
phospho-scrA [cytosol]
(Dictyostelium discoideum)
phospho-WASF3 [cytosol]
(Bos taurus)
phospho-WASF3 [cytosol]
(Canis familiaris)
phospho-WASF3 [cytosol]
(Gallus gallus)
phospho-WASF3 [cytosol]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 151
Coordinate
151
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.527
2
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