Reactome | ARF6 [recycling endosome membrane]

ARF6 [recycling endosome membrane]

Stable Identifier

R-HSA-2029049

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

recycling endosome membrane

Synonyms

ADP-ribosylation factor 6, ARF6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62330 ARF6

Gene Names

ARF6

Chain

initiator methionine:, chain:2-175

Reference Genes

BioGPS Gene:382 ARF6

COSMIC (genes):ARF6 ARF6

CTD Gene:382 ARF6

dbSNP Gene:382 ARF6

ENSEMBL:ENSG00000165527 ARF6

ENSEMBL_homo_sapiens_GENE:ENSG00000165527.8 ARF6

HGNC:659 ARF6

KEGG Gene (Homo sapiens):382 ARF6

Monarch:382 ARF6

NCBI Gene:382 ARF6

OMIM:600464 ARF6

UCSC:P62330 ARF6

Reference Transcript

RefSeq:NM_001663.3 ARF6

Other Identifiers

11717401_at

11717402_s_at

11758273_s_at

16783974

203311_PM_s_at

203311_s_at

203312_PM_x_at

203312_x_at

224788_PM_at

224788_at

2631342

3063398

3063399

33152_at

3535001

3535002

3535003

3535004

3535005

3535006

3535007

3535008

3535009

3535010

382

43480_at

54829_s_at

54831_r_at

7974249

A_14_P107803

A_23_P48691

A_24_P472455

GE58261

GO:0000166

GO:0001726

GO:0001889

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005737

GO:0005768

GO:0005769

GO:0005794

GO:0005829

GO:0005886

GO:0005925

GO:0005938

GO:0006886

GO:0007010

GO:0007049

GO:0007155

GO:0007163

GO:0007399

GO:0010008

GO:0010975

GO:0010976

GO:0012501

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0019003

GO:0023052

GO:0030139

GO:0030154

GO:0030838

GO:0030866

GO:0031410

GO:0031527

GO:0031901

GO:0031996

GO:0032154

GO:0032456

GO:0034330

GO:0034394

GO:0035020

GO:0035591

GO:0036010

GO:0042995

GO:0043226

GO:0048261

GO:0048488

GO:0048856

GO:0048870

GO:0050714

GO:0051301

GO:0051489

GO:0051549

GO:0055037

GO:0055038

GO:0060090

GO:0060998

GO:0065003

GO:0070062

GO:0072659

GO:0090162

GO:0090543

GO:0097178

GO:0097284

GO:0098772

GO:0098793

GO:0098794

GO:0098978

GO:0099562

GO:0120183

GO:1902217

GO:1903078

GO:1905606

GO:1990090

GO:2000009

GO:2000171

HMNXSV003016641

Hs.180777.0.A1_3p_at

M57763_at

TC14000280.hg

TC14001678.hg

g178988_3p_a_at

g6996000_3p_a_at

Participates

as a component of

ARF6:GTP [recycling endosome membrane] (Homo sapiens)

Other forms of this molecule

ARF6 [cytosol]

Inferred To

ARF6 [recycling endosome membrane] (Bos taurus)

ARF6 [recycling endosome membrane] (Canis familiaris)

ARF6 [recycling endosome membrane] (Drosophila melanogaster)

ARF6 [recycling endosome membrane] (Gallus gallus)

ARF6 [recycling endosome membrane] (Mus musculus)

ARF6 [recycling endosome membrane] (Rattus norvegicus)

ARF6 [recycling endosome membrane] (Sus scrofa)

Ghost homologue of ARF6 [recycling endosome membrane] (Xenopus tropicalis)

arf6b [recycling endosome membrane] (Danio rerio)

arf-6 [recycling endosome membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001654.1

OpenTargets

ENSG00000165527

HPA

ENSG00000165527-ARF6

GeneCards

P62330

Ensembl

ENST00000298316, ENSG00000165527, ENST00000693319, ENSP00000510419, ENSP00000298316

PRO

P62330

Pharos - Targets

P62330

HMDB Protein

HMDBP08304

PDB

3LVQ, 6BBQ, 2A5D, 4KAX, 6PAU, 7RK3, 3PCR, 6BBP, 2A5F, 2W83, 7XRD, 2BAO, 2A5G, 4FME, 2BAU, 3N5C, 2J5X, 3LVR, 1E0S

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02241 KIF23	3	KIF23 [nucleoplasm] (R-HSA-156709) p-S911,S912-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [cytosol] (R-HSA-1015863)	0.667	23
UniProt:O00213 APBB1	1	APBB1 [nucleoplasm] (R-HSA-5683987)	0.633	9
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.618	8
UniProt:Q9NZ52 GGA3	3	GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [recycling endosome membrane] (R-HSA-8875655) GGA3 [early endosome membrane] (R-HSA-8854137)	0.589	3
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.57	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q8N307 MUC20	19	Core 8 (MUC20) [Golgi lumen] (R-HSA-1462329) Core 2S (MUC20) [Golgi lumen] (R-HSA-6786382) Core 5 (MUC20) [Golgi lumen] (R-HSA-1462128) Core 4 (MUC20) [Golgi lumen] (R-HSA-1462266) Core 3 (MUC20) [Golgi lumen] (R-HSA-1462344) Core 7 (MUC20) [Golgi lumen] (R-HSA-1462236) extended Core 6 (MUC20) [Golgi lumen] (R-HSA-1967016) Core 6 (MUC20) [Golgi lumen] (R-HSA-1462247) MUC20 [Golgi lumen] (R-HSA-913634) Disialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463482) Sialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463469) Sialyl-2,3 T-antigen (MUC20) [Golgi lumen] (R-HSA-1463479) T-antigen (MUC20) [Golgi lumen] (R-HSA-1462188) Sialyl Tn antigen (MUC20) [Golgi lumen] (R-HSA-1463558) GalNAc-MUC20 [Golgi lumen] (R-HSA-1463443) Core 2a (MUC20) [Golgi lumen] (R-HSA-6784267) Core 2 (MUC20) [Golgi lumen] (R-HSA-1462330) GalNAc-MUC20 [plasma membrane] (R-HSA-8858516) MUC20 [plasma membrane] (R-HSA-8851833)	0.527	2
UniProt:P21283 ATP6V1C1	1	ATP6V1C1 [cytosol] (R-HSA-912586)	0.524	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10

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