Reactome | PDK1 [mitochondrial matrix]

PDK1 [mitochondrial matrix]

Stable Identifier

R-HSA-203944

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Pyruvate dehydrogenase kinase isoform 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15118 PDK1

Gene Names

PDK1, PDHK1

Chain

transit peptide:1-28, chain:29-436

Reference Genes

BioGPS Gene:5163 PDK1

COSMIC (genes):PDK1 PDK1

CTD Gene:5163 PDK1

dbSNP Gene:5163 PDK1

ENSEMBL:ENSG00000152256 PDK1

ENSEMBL_homo_sapiens_GENE:ENSG00000152256.14 PDK1

HGNC:8809 PDK1

KEGG Gene (Homo sapiens):5163 PDK1

Monarch:5163 PDK1

NCBI Gene:5163 PDK1

OMIM:602524 PDK1

UCSC:Q15118 PDK1

Reference Transcript

Other Identifiers

11733981_a_at

11733982_a_at

16887736

206686_PM_at

206686_at

226452_PM_at

226452_at

239798_PM_at

239798_at

2515711

2515712

2515713

2515715

2515716

2515717

2515718

2515719

2515720

2515721

2515723

2515725

2515726

2515727

2515728

2515729

2515730

2515731

2515732

2515733

2515734

2515735

2515736

2515753

2515755

2515757

2515758

2515760

2515762

2515764

2515766

2515768

2515770

2515771

2515773

2515775

36386_at

5163

53964_at

61169_at

62671_at

76868_at

8046408

A_14_P202066

A_23_P10614

A_24_P37441

GE57774

GE583119

GE886910

GO:0000166

GO:0003824

GO:0004672

GO:0004740

GO:0005515

GO:0005524

GO:0005739

GO:0005759

GO:0005967

GO:0005975

GO:0006006

GO:0006629

GO:0006790

GO:0008283

GO:0008631

GO:0010510

GO:0010906

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0043226

GO:0055086

GO:0097411

GO:0140096

GO:1901135

HMNXSV003001764

HMNXSV003014073

Hs.18200.0.A1_3p_at

Hs.61712.1.S1_3p_at

ILMN_1670256

L42450_at

PH_hs_0015647

PH_hs_0033324

TC02001031.hg

g7108358_3p_at

Participates

as a member of

as a component of

Inferred To

pdk1 [mitochondrial matrix] (Xenopus tropicalis)

PDK1 [mitochondrial matrix] (Bos taurus)

PDK1 [mitochondrial matrix] (Caenorhabditis elegans)

PDK1 [mitochondrial matrix] (Canis familiaris)

PDK1 [mitochondrial matrix] (Drosophila melanogaster)

PDK1 [mitochondrial matrix] (Gallus gallus)

PDK1 [mitochondrial matrix] (Mus musculus)

PDK1 [mitochondrial matrix] (Rattus norvegicus)

PDK1 [mitochondrial matrix] (Schizosaccharomyces pombe)

PDK1 [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_001265478.1, NP_002601.1

Guide to Pharmacology - Targets

2915

OpenTargets

ENSG00000152256

ZINC - Substances

PDK1_HUMAN

ZINC target

Q15118

PRO

Q15118

PDB

2Q8G, 2Q8F, 2Q8H

ZINC - Investigational

PDK1_HUMAN

GeneCards

Q15118

HPA

ENSG00000152256-PDK1

Ensembl

ENSP00000386985, ENSG00000152256, ENST00000282077, ENSP00000282077, ENST00000392571, ENST00000410055, ENSP00000376352

Pharos - Targets

Q15118

ZINC - Predictions - Purchasable

PDK1_HUMAN

HMDB Protein

HMDBP01172

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15119 PDK2	1	PDK2(?-407) [mitochondrial matrix] (R-HSA-203943)	0.706	5
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P00403 MT-CO2	2	nascent MT-CO2 [mitochondrial matrix] (R-HSA-9902095) nascent MT-CO2 [mitochondrial inner membrane] (R-HSA-164302)	0.463	2