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DFFA(225-331) [nucleoplasm]
Stable Identifier
R-HSA-211188
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DFF45 fragment (225-331)
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptosis induced DNA fragmentation (Homo sapiens)
Cleavage of DFF45 (224) by caspase-3 (Homo sapiens)
caspase-3-cleaved DFFA (117,224):DFFB complex [nucleoplasm] (Homo sapiens)
DFFA(225-331) [nucleoplasm] (Homo sapiens)
Cleaved fragments of DFF45 dissociate from DFF40 (Homo sapiens)
DFFA(225-331) [nucleoplasm] (Homo sapiens)
caspase-3-cleaved DFFA (117,224):DFFB complex [nucleoplasm] (Homo sapiens)
DFFA(225-331) [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00273 DFFA
Gene Names
DFFA, DFF1, DFF45, H13
Chain
chain:1-331
Reference Genes
BioGPS Gene:1676 DFFA
COSMIC (genes):DFFA DFFA
CTD Gene:1676 DFFA
dbSNP Gene:1676 DFFA
ENSEMBL:ENSG00000160049 DFFA
ENSEMBL_homo_sapiens_GENE:ENSG00000160049.12 DFFA
HGNC:2772 DFFA
KEGG Gene (Homo sapiens):1676 DFFA
Monarch:1676 DFFA
NCBI Gene:1676 DFFA
OMIM:601882 DFFA
UCSC:O00273 DFFA
Reference Transcript
RefSeq:NM_213566.1 DFFA
RefSeq:NM_004401.2 DFFA
Other Identifiers
11726261_at
11726262_a_at
11726263_x_at
11739517_x_at
16681531
1676
203277_3p_at
203277_PM_at
203277_at
223518_PM_at
223518_at
226116_PM_at
226116_at
2396120
2396122
2396123
2396124
2396125
2396126
2396127
2396128
2396129
2396130
2396131
2396132
2396133
2396134
32047_at
62173_at
7912303
86020_at
91741_at
A_23_P12189
A_24_P222758
GE59567
GE702566
GO:0000785
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0006309
GO:0006457
GO:0006915
GO:0012501
GO:0019904
GO:0032076
GO:0032991
GO:0043065
GO:0043226
GO:0044183
GO:0060703
GO:0061077
GO:0070242
GO:0098772
GO:1900118
GO:1902511
HMNXSV003002035
HMNXSV003026002
Hs.48617.0.S1_3p_at
ILMN_1667213
ILMN_2385220
PH_hs_0003404
PH_hs_0026477
TC01002190.hg
U91985_at
g4758147_3p_at
g4758147_3p_x_at
g4926917_3p_at
Participates
as an output of
Cleaved fragments of DFF45 dissociate from DFF40 (Homo sapiens)
as a component of
caspase-3-cleaved DFFA (117,224):DFFB complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
DFFA [cytosol]
DFFA(1-?) [nucleoplasm]
DFFA(118-224) [nucleoplasm]
DFFA(118-331) [nucleoplasm]
DFFA(1-117) [nucleoplasm]
Inferred To
DFFA(225-331) [nucleoplasm]
(Gallus gallus)
DFFA [nucleoplasm]
(Bos taurus)
DFFA [nucleoplasm]
(Canis familiaris)
DFFA [nucleoplasm]
(Sus scrofa)
dffa [nucleoplasm]
(Danio rerio)
dffa [nucleoplasm]
(Xenopus tropicalis)
Dffa [nucleoplasm]
(Mus musculus)
Dffa [nucleoplasm]
(Rattus norvegicus)
Drep1 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_998731.1
,
NP_004392.1
OpenTargets
ENSG00000160049
HPA
ENSG00000160049-DFFA
GeneCards
O00273
Ensembl
ENSP00000366237
,
ENSG00000160049
,
ENST00000377038
,
ENST00000377036
,
ENSP00000366235
PRO
O00273
Pharos - Targets
O00273
PDB
1IBX
,
1KOY
,
1IYR
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76075 DFFB
2
DFFB [cytosol]
(R-HSA-211211)
DFFB [nucleoplasm]
(R-HSA-211195)
0.909
10
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.589
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.589
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.508
2
UniProt:Q9UJ04 TSYL4
0.499
2
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