Transcriptional activation of mitochondrial biogenesis

Stable Identifier
Homo sapiens
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Phosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate the transcription of nuclear-encoded, mitochondrially targeted proteins such as TFB2M, TFB1M, and TFAM. PGC-1beta and PPRC appear to act similarly to PGC-1alpha but have not been as well studied. Transcription of PPARGC1A itself is upregulated by CREB1 (in response to calcium), MEF2C/D, ATF2, and PPARGC1A. Transcription of PPARGC1A is repressed by NR1D1 (REV-ERBA).

Literature References
PubMed ID Title Journal Year
19575678 Transcriptional control of mitochondrial biogenesis and function

Kralli, A, Hock, MB

Annu Rev Physiol 2009
22265687 Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes

Suliman, HB, Piantadosi, CA

Biochim. Biophys. Acta 2012
19682549 Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging

Saleem, A, Joseph, AM, Nguyen, LM, Collu-Marchese, M, Ljubicic, V, Uguccioni, G, Hood, DA, Lai, RY

Biochim Biophys Acta 2010
20933024 Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

Scarpulla, RC

Biochim Biophys Acta 2011
22817841 Transcriptional integration of mitochondrial biogenesis

Scarpulla, RC, Kelly, DP, Vega, RB

Trends Endocrinol. Metab. 2012
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