Reactome | ANO1 [plasma membrane]

ANO1 [plasma membrane]

Stable Identifier

R-HSA-2684927

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Anoctamin-1, ANO1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q5XXA6 ANO1

Gene Names

ANO1, DOG1, ORAOV2, TAOS2, TMEM16A

Chain

chain:1-986

Reference Genes

BioGPS Gene:55107 ANO1

COSMIC (genes):ANO1 ANO1

CTD Gene:55107 ANO1

dbSNP Gene:55107 ANO1

ENSEMBL:ENSG00000131620 ANO1

HGNC:21625 ANO1

KEGG:hsa:55107 ANO1

Monarch:55107 ANO1

NCBI Gene:55107 ANO1

OMIM:610108 ANO1

UCSC:Q5XXA6 ANO1

Reference Transcript

Other Identifiers

11723828_a_at

11723829_s_at

11723830_x_at

1555269_PM_a_at

1555269_a_at

16728287

218804_PM_at

218804_at

3338301

3338302

3338303

3338321

3338322

3338323

3338324

3338325

3338326

3338327

3338336

3338337

3338339

3338340

3338341

3338343

3338344

3338345

3338346

3338347

3338349

3338350

3338352

3338355

3338360

3338361

3338363

3338366

3338367

3338368

3338369

3338370

3338371

3338372

3338374

3338375

3338379

3338380

3338381

3338383

3338384

3338386

3338387

3338388

3338389

3338390

3338391

43366_at

43963_at

55107

7942135

A_14_P128437

A_23_P98304

A_24_P110831

A_24_P87036

A_33_P3381292

GE82285

GO:0005102

GO:0005215

GO:0005227

GO:0005229

GO:0005247

GO:0005254

GO:0005515

GO:0005654

GO:0005886

GO:0006821

GO:0007200

GO:0015111

GO:0015705

GO:0016020

GO:0016324

GO:0034220

GO:0034605

GO:0034707

GO:0035774

GO:0042802

GO:0042803

GO:0042995

GO:0043226

GO:0045202

GO:0046872

GO:0046983

GO:0050965

GO:0055085

GO:0070062

GO:0070254

GO:0072657

GO:0098655

GO:0098793

GO:0106091

GO:1901653

GO:1902476

HMNXSV003008747

HMNXSV003008768

HMNXSV003019302

Hs2.26176.2.S1_3p_s_at

ILMN_1717909

ILMN_2091310

PH_hs_0040955

TC11000721.hg

TC11002761.hg

g8922319_3p_at

p33664

Participates

as a component of

ANO1:ANO1 inhibitors [plasma membrane] (Homo sapiens)

as an input of

ANO1 inhibitors bind ANO1 (Homo sapiens)

as a member of

ANOs [plasma membrane] (Homo sapiens)

Inferred To

Ano1 [plasma membrane] (Rattus norvegicus)

IST2 [plasma membrane] (Saccharomyces cerevisiae)

ANO1 [plasma membrane] (Bos taurus)

ANO1 [plasma membrane] (Canis familiaris)

ANO1 [plasma membrane] (Dictyostelium discoideum)

ANO1 [plasma membrane] (Gallus gallus)

ANO1 [plasma membrane] (Mus musculus)

ANO1 [plasma membrane] (Schizosaccharomyces pombe)

ANO1 [plasma membrane] (Sus scrofa)

ano1 [plasma membrane] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

708

ENSEMBL

ENST00000355303, ENSP00000319477, ENSG00000131620, ENSP00000435797, ENST00000531349, ENSP00000432843, ENST00000530676, ENST00000316296, ENSP00000347454

OpenTargets

ENSG00000131620

GeneCards

ANO1

HPA

ENSG00000131620-ANO1

ZINC - Substances

ANO1_HUMAN

ZINC target

Q5XXA6

PRO

Q5XXA6

Pharos - Targets

Q5XXA6

GlyGen

Q5XXA6

HMDB Protein

HMDBP07439

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.463	2