Reactome | Activation of NIMA Kinases NEK9, NEK6, NEK7

Activation of NIMA Kinases NEK9, NEK6, NEK7

Stable Identifier

R-HSA-2980767

DOI

10.3180/REACT_160122.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Activation of NIMA Kinases NEK9, NEK6, NEK7

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NEK6 and NEK7 are activated during mitosis by another NIMA family kinase, NEK9 (Belham et al. 2003, Richards et al. 2009), which is activated by CDK1- and PLK1-mediated phosphorylation (Roig et al. 2002, Bertran et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
19941817	An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9 Cheung, J, O'Regan, L, Hoelder, S, Richards, MW, Bayliss, R, Fry, AM, Blot, JM, Mas-Droux, C	Mol. Cell	2009
21642957	Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 Sdelci, S, Bertran, MT, Avruch, J, Roig, J, Caelles, C, Regué, L	EMBO J.	2011
12840024	A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases Aoyama, Y, Kemp, BE, Avruch, J, Belham, C, Roig, J, Caldwell, JA, Comb, M	J. Biol. Chem.	2003
12101123	Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression Avruch, J, Belham, C, Roig, J, Mikhailov, A	Genes Dev.	2002