Reactome | SUMO is proteolytically processed

SUMO is proteolytically processed

Stable Identifier

R-HSA-3065679

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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General

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SUMO1, 2, and 3 are initially expressed as propeptides containing extra residues at the C-terminus. (SUMO1 has 4 residues, SUMO2 has 2 residues, and SUMO3 has 11 residues,) SENP1, 2, and 5 are endoproteases that process the precursors to produce the mature peptides (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). SENP1 processes SUMO1 with greater efficiency than SUMO2 or SUMO3. SENP2 and SENP5 process SUMO2 with greater efficiency than SUMO1 or SUMO3 (Gong and Yeh 2006, Mikolajczyk et al. 2007). SENP1 shuttles between the cytosol and nuceoplasm and is predominantly nuclear (Bailey and O'hare 2004, Kim et al. 2005). SENP2 also shuttles (Itahana et al. 2006) and is mainly located on nucleoplasmic filaments of the nuclear pore complex (Hang and Dasso 2002, Zhang et al. 2002). SENP5 is located mostly in the nucleolus (Di Bacco et al. 2006, Gong and Yeh 2006).

Literature References

PubMed ID	Title	Journal	Year
17591783	Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs Békés, M, Drag, M, Ronai, Z, Cao, JT, Mikolajczyk, J, Salvesen, GS	J. Biol. Chem.	2007
14563852	Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1 O'Hare, P, Bailey, D	J. Biol. Chem.	2004
16608850	Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 Yeh, ET, Gong, L	J. Biol. Chem.	2006
12192048	Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex Zhang, H, Matunis, MJ, Saitoh, H	Mol. Cell. Biol.	2002
20674646	Post-translational modification by SUMO Hay, RT, Hannoun, Z, Jaffray, E, Greenhough, S, Hay, DC	Toxicology	2010
16738315	The SUMO-specific protease SENP5 is required for cell division Ploegh, H, Catic, A, Gill, G, Lee, HY, Ouyang, J, Di Bacco, A	Mol. Cell. Biol.	2006
16253240	Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1 Lee, SJ, Kim, Y, Sung, KS, Choi, CY, Kim, YO, Kim, YH	FEBS Lett.	2005
19923268	SUMOylation and deSUMOylation at a glance Dasso, M, Wang, Y	J. Cell. Sci.	2009
16738331	Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2 Yeh, ET, Zhang, Y, Itahana, Y	Mol. Cell. Biol.	2006
20462400	Mechanisms, regulation and consequences of protein SUMOylation Henley, JM, Wilkinson, KA	Biochem. J.	2010
11896061	Association of the human SUMO-1 protease SENP2 with the nuclear pore Dasso, M, Hang, J	J. Biol. Chem.	2002
21102611	The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition Gareau, JR, Lima, CD	Nat. Rev. Mol. Cell Biol.	2010