Reactome | Thyroxine is deiodinated to reverse triiodothyronine (RT3)

Thyroxine is deiodinated to reverse triiodothyronine (RT3)

Stable Identifier

R-HSA-350869

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Thyroxine is deiodinated to reverse triiodothyronine (RT3)

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Type III iodothyronine deiodinase (DIO3) is an integral membrane protein (Baqui M et al, 2003) and catalyzes the conversion of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). Both RT3 and T2 are inactive metabolites. It is thought DIO3 plays an essential role for regulation of thyroid hormone inactivation during embryological development.

Literature References

PubMed ID	Title	Journal	Year
7593630	Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme Salvatore, D, Low, SC, Berry, M, Maia, AL, Harney, JW, Croteau, W, St Germain, DL, Larsen, PR	J Clin Invest	1995