Reactome | Translocation of RIAM to plasma membrane

Translocation of RIAM to plasma membrane

Stable Identifier

R-HSA-354060

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Translocation of RIAM to plasma membrane

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Upon the production of activated Rap1A at the plasma membrane, RIAM interacts with Rap1A-GTP with its N-ter RA domain, and with its C-ter PH domain it interacts with PIP2.

Literature References

PubMed ID	Title	Journal	Year
16757337	Rap1 regulation of RIAM and cell adhesion Boussiotis, VA, Lafuente, E	Methods Enzymol	2006
17624957	Platelet integrins and immunoreceptors Kasirer-Friede, A, Kahn, ML, Shattil, SJ	Immunol Rev	2007
15469846	RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion Constantine, E, Krause, M, van Puijenbroek, AA, Springer, TA, Lafuente, EM, Gertler, FB, Carman, CV, Freeman, GJ, Berezovskaya, A, Boussiotis, VA	Dev Cell	2004