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CDK5RAP2 [cytosol]
Stable Identifier
R-HSA-380282
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cep215
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
Association of NuMA with microtubules (Homo sapiens)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Translocation of NuMA to the centrosomes (Homo sapiens)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
AURKA Activation by TPX2 (Homo sapiens)
TPX2 binds AURKA at centrosomes (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
TPX2 promotes AURKA autophosphorylation (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Centrosome maturation (Homo sapiens)
Loss of proteins required for interphase microtubule organization from the centrosome (Homo sapiens)
Loss of C-Nap-1 from centrosomes (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Loss of Nlp from mitotic centrosomes (Homo sapiens)
Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Plk1-mediated phosphorylation of Nlp (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
Recruitment of CDK11p58 to the centrosomes (Homo sapiens)
Centrosomes containing recruited CDK11p58 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Recruitment of Plk1 to centrosomes (Homo sapiens)
Centrosome associated Plk1 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
AJUBA binds centrosome-associated AURKA (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Centrosome:AURKA:AJUBA [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
AJUBA facilitates AURKA autophosphorylation (Homo sapiens)
Centrosome:AURKA:AJUBA [cytosol] (Homo sapiens)
Centrosome:AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
AURKA phosphorylates PLK1 (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
BORA binds PLK1 and AURKA (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Anchoring of the basal body to the plasma membrane (Homo sapiens)
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
C2CD3 binds the mother centriole (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
CP110 and CEP97 dissociate from the centriole (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
MARK4 binds ODF2 in the centriole (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Recruitment of transition zone proteins (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
basal body:transition zone proteins [cytosol] (Homo sapiens)
basal body [cytosol] (Homo sapiens)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
The distal appendage proteins recruit TTBK2 (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
mother centriole:C2CD3 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDK5RAP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96SN8 CDK5RAP2
Gene Names
CDK5RAP2, CEP215, KIAA1633
Chain
chain:1-1893
Reference Genes
BioGPS Gene:55755 CDK5RAP2
COSMIC (genes):CDK5RAP2 CDK5RAP2
CTD Gene:55755 CDK5RAP2
dbSNP Gene:55755 CDK5RAP2
ENSEMBL:ENSG00000136861 CDK5RAP2
HGNC:18672 CDK5RAP2
KEGG:hsa:55755 CDK5RAP2
Monarch:55755 CDK5RAP2
NCBI Gene:55755 CDK5RAP2
OMIM:608201 CDK5RAP2
UCSC:Q96SN8 CDK5RAP2
Reference Transcript
RefSeq:NM_018249.5 CDK5RAP2
RefSeq:NM_001011649.2 CDK5RAP2
RefSeq:NM_001272039.1 CDK5RAP2
RefSeq:XM_006717182.1 CDK5RAP2
Other Identifiers
11724523_a_at
11724524_x_at
11725276_a_at
11748991_a_at
11758253_s_at
17097813
220935_PM_s_at
220935_s_at
233540_PM_s_at
233540_s_at
237418_PM_at
237418_at
243153_PM_at
243153_at
3223445
3223446
3223447
3223448
3223449
3223450
3223451
3223452
3223453
3223454
3223455
3223456
3223457
3223458
3223459
3223460
3223461
3223462
3223463
3223464
3223465
3223466
3223467
3223468
3223469
3223470
3223471
3223472
3223473
3223474
3223475
3223476
3223477
3223478
3223479
3223480
3223481
3223482
3223483
3223484
3223490
3223491
3223492
3223493
3223494
3223495
3223496
3223497
3223498
3223499
3223501
3223502
3223504
3223505
3223507
3223512
3223513
3223515
3223516
3223517
3223519
3223520
3223521
3223523
3223525
3223526
3223527
3223531
3223532
3223533
3223535
3223537
3223541
3223542
3223543
3223546
3223547
3223548
3223549
3223550
43180_at
44683_at
55755
66078_at
70707_at
8163733
A_23_P83110
A_33_P3389060
GE82329
GE861734
GE885810
GO:0000132
GO:0000226
GO:0000242
GO:0000922
GO:0000931
GO:0000976
GO:0001578
GO:0003677
GO:0005515
GO:0005516
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005874
GO:0006355
GO:0007010
GO:0007059
GO:0007098
GO:0007099
GO:0007420
GO:0008017
GO:0008092
GO:0015631
GO:0016020
GO:0019901
GO:0022008
GO:0030054
GO:0030154
GO:0031023
GO:0031116
GO:0035371
GO:0043015
GO:0043226
GO:0044877
GO:0045664
GO:0045665
GO:0045893
GO:0046600
GO:0048471
GO:0048856
GO:0070062
GO:0090266
GO:0097431
HMNXSV003045591
HMNXSV003052824
Hs.191212.0.A1_3p_at
Hs.209105.0.A1_3p_at
Hs.32360.2.S1_3p_a_at
ILMN_1655990
ILMN_1725235
ILMN_2415529
PH_hs_0025648
PH_hs_0036876
TC09001536.hg
g8922723_3p_a_at
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
Inferred To
Cdk5rap2 [cytosol]
(Mus musculus)
Cdk5rap2 [cytosol]
(Rattus norvegicus)
CDK5RAP2 [cytosol]
(Bos taurus)
CDK5RAP2 [cytosol]
(Canis familiaris)
CDK5RAP2 [cytosol]
(Sus scrofa)
cdk5rap2 [cytosol]
(Xenopus tropicalis)
Ghost homologue of CDK5RAP2 [cytosol]
(Gallus gallus)
Cross References
RefSeq
NP_001011649.1
,
NP_001258968.1
,
XP_006717245.1
,
NP_060719.4
ENSEMBL
ENST00000360190
,
ENSP00000353317
,
ENSP00000343818
,
ENSP00000400395
,
ENST00000416449
,
ENST00000349780
OpenTargets
ENSG00000136861
HPA
ENSG00000136861-CDK5RAP2
PRO
Q96SN8
Pharos - Targets
Q96SN8
GlyGen
Q96SN8
Orphanet
CDK5RAP2
PDB
6X0V
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17612 PRKACA
4
PRKACA [cytosol]
(R-HSA-57844)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
0.725
6
UniProt:Q9H444 CHMP4B
2
CHMP4B [cytosol]
(R-HSA-917708)
CHMP4B [endosome membrane]
(R-HSA-9631202)
0.527
3
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.499
3
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