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TPM4 [cytosol]
Stable Identifier
R-HSA-390548
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tropomyosin alpha-4 chain, TPM4_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Calcium Binds Caldesmon (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Striated Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Calcium Binds Troponin-C (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOV GTPase cycle (Homo sapiens)
RHOV binds effectors at the plasma membrane (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
TPM4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P67936 TPM4
Gene Names
TPM4
Chain
initiator methionine:, chain:2-248
Reference Genes
BioGPS Gene:7171 TPM4
COSMIC (genes):TPM4 TPM4
CTD Gene:7171 TPM4
dbSNP Gene:7171 TPM4
ENSEMBL:ENSG00000167460 TPM4
ENSEMBL_homo_sapiens_GENE:ENSG00000167460.17 TPM4
HGNC:12013 TPM4
KEGG Gene (Homo sapiens):7171 TPM4
Monarch:7171 TPM4
NCBI Gene:7171 TPM4
OMIM:600317 TPM4
UCSC:P67936 TPM4
Reference Transcript
RefSeq:NM_003290.2 TPM4
RefSeq:NM_001145160.1 TPM4
Other Identifiers
11727782_a_at
11727783_s_at
11727784_x_at
11748400_s_at
11748401_x_at
1567107_PM_s_at
1567107_s_at
16859253
17123152
17123154
17124988
209344_PM_at
209344_at
212481_PM_s_at
212481_s_at
2614801
2614803
2614804
3102324
3102327
3102328
33866_at
3823515
3823516
3823517
3823519
3823521
3823522
3823528
3823532
3823534
3823536
3823538
3823539
3823543
3823544
3823545
3823546
3823547
3823548
3823549
3823550
7171
8026513
8180349
A_23_P141974
A_24_P82880
A_32_P28284
GE61356
GO:0001649
GO:0001725
GO:0002102
GO:0003012
GO:0003779
GO:0005198
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005856
GO:0005862
GO:0005884
GO:0005925
GO:0006936
GO:0007010
GO:0007015
GO:0008092
GO:0008307
GO:0016020
GO:0030154
GO:0030863
GO:0042802
GO:0042803
GO:0043226
GO:0046872
GO:0046982
GO:0051015
GO:0070062
HMNXSV003043181
HMNXSV003052535
Hs.250641.1.S1_3p_a_at
Hs2.438676.1.S1_3p_s_at
PH_hs_0027325
TC19000316.hg
X05276_at
g12803958_3p_x_at
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
as a member of
Tropomyosin [cytosol] (Homo sapiens)
Other forms of this molecule
TPM4(2-222)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
TPM4(2-222)insV-ALK(1059-1620) fusion [cytosol]
Inferred To
TPM1 [cytosol]
(Saccharomyces cerevisiae)
Tpm4 [cytosol]
(Mus musculus)
Tpm4 [cytosol]
(Rattus norvegicus)
tmp4 [cytosol]
(Danio rerio)
Tm1 [cytosol]
(Drosophila melanogaster)
cdc8 [cytosol]
(Schizosaccharomyces pombe)
Homologues of TPM4 [cytosol]
(Danio rerio)
Homologues of TPM4 [cytosol]
(Drosophila melanogaster)
lev-11 [cytosol]
(Caenorhabditis elegans)
Tm2 [cytosol]
(Drosophila melanogaster)
tpm4 [cytosol]
(Danio rerio)
TPM4 [cytosol]
(Gallus gallus)
TPM4 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_003281.1
,
NP_001138632.1
OpenTargets
ENSG00000167460
HPA
ENSG00000167460-TPM4
GeneCards
P67936
Ensembl
ENST00000643579
,
ENSP00000495347
,
ENSP00000494125
,
ENST00000646974
,
ENSG00000167460
PRO
P67936
Pharos - Targets
P67936
Orphanet
22225
HMDB Protein
HMDBP01770
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
19
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
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